| NAD+ cleavage activity by animal and plant TIR domains in cell death pathways S Horsefield, H Burdett, X Zhang, MK Manik, Y Shi, J Chen, T Qi, J Gilley, ... Science 365 (6455), 793-799, 2019 | 464 | 2019 |
| SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration MD Figley, W Gu, JD Nanson, Y Shi, Y Sasaki, K Cunnea, AK Malde, X Jia, ... Neuron 109 (7), 1118-1136. e11, 2021 | 239 | 2021 |
| Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling MK Manik, Y Shi, S Li, MA Zaydman, N Damaraju, S Eastman, TG Smith, ... Science 377 (6614), eadc8969, 2022 | 100 | 2022 |
| Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules Y Shi, PS Kerry, JD Nanson, T Bosanac, Y Sasaki, R Krauss, FK Saikot, ... Molecular cell 82 (9), 1643-1659. e10, 2022 | 90 | 2022 |
| Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation Y Shi, BM Pinto PLoS One 9 (1), e86365, 2014 | 56 | 2014 |
| Inhibitor discovery of full-length New Delhi metallo-β-lactamase-1 (NDM-1) B Shen, Y Yu, H Chen, X Cao, X Lao, Y Fang, Y Shi, J Chen, H Zheng PLoS One 8 (5), e62955, 2013 | 55 | 2013 |
| How size matters: diversity for fragment library design Y Shi, M von Itzstein Molecules 24 (15), 2838, 2019 | 48 | 2019 |
| Probing the effect of the non-active-site mutation Y229W in New Delhi metallo-β-lactamase-1 by site-directed mutagenesis, kinetic studies, and molecular dynamics simulations J Chen, H Chen, Y Shi, F Hu, X Lao, X Gao, H Zheng, W Yao PLoS One 8 (12), e82080, 2013 | 39 | 2013 |
| Unravelling the Role of O-glycans in Influenza A Virus Infection J Mayr, K Lau, JCC Lai, IA Gagarinov, Y Shi, S McAtamney, RWY Chan, ... Scientific reports 8 (1), 16382, 2018 | 38 | 2018 |
| Effects of data quality and quantity on deep learning for protein-ligand binding affinity prediction FJ Fan, Y Shi Bioorganic & Medicinal Chemistry 72, 117003, 2022 | 33 | 2022 |
| Design of glycosyltransferase inhibitors targeting human O-GlcNAc transferase (OGT) S Wang, DL Shen, D Lafont, AS Vercoutter-Edouart, M Mortuaire, Y Shi, ... MedChemComm 5 (8), 1172-1178, 2014 | 31 | 2014 |
| Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection Y Sasaki, J Zhu, Y Shi, W Gu, B Kobe, T Ve, A DiAntonio, J Milbrandt Experimental Neurology 345, 113842, 2021 | 29 | 2021 |
| Enhancing vaccine efficacy by engineering a complex synthetic peptide to become a super immunogen T Nordström, M Pandey, A Calcutt, J Powell, ZN Phillips, G Yeung, ... The Journal of Immunology 199 (8), 2794-2802, 2017 | 23 | 2017 |
| Specificity of a UDP‐GalNAc Pyranose–Furanose Mutase: A Potential Therapeutic Target for Campylobacter jejuni Infections MB Poulin, Y Shi, C Protsko, SA Dalrymple, DAR Sanders, BM Pinto, ... ChemBioChem 15 (1), 47-56, 2014 | 22* | 2014 |
| Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells J Chen, J Yang, Q Wei, L Weng, F Wu, Y Shi, X Cheng, X Cai, C Hu, ... Cell Communication and Signaling 18, 1-12, 2020 | 17 | 2020 |
| A Second, Druggable Binding Site in UDP‐Galactopyranose Mutase from Mycobacterium tuberculosis? Y Shi, C Colombo, JRA Kuttiyatveetil, N Zalatar, KE van Straaten, ... ChemBioChem 17 (23), 2264-2273, 2016 | 16 | 2016 |
| Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities HY McGuinness, W Gu, Y Shi, B Kobe, T Ve The Neuroscientist 30 (4), 473-492, 2024 | 13 | 2024 |
| Toll/interleukin-1 receptor domains in bacterial and plant immunity S Li, MK Manik, Y Shi, B Kobe, T Ve Current Opinion in Microbiology 74, 102316, 2023 | 12 | 2023 |
| TIR domain-associated nucleotides with functions in plant immunity and beyond N Maruta, M Sorbello, BYJ Lim, HY McGuinness, Y Shi, T Ve, B Kobe Current Opinion in Plant Biology 73, 102364, 2023 | 9 | 2023 |
| Novel bisubstrate uridine-peptide analogues bearing a pyrophosphate bioisostere as inhibitors of human O-GlcNAc transferase P Ryan, Y Shi, M von Itzstein, S Rudrawar Bioorganic Chemistry 110, 104738, 2021 | 5 | 2021 |