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Rebecca Crawshaw
Rebecca Crawshaw
manchester.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
The road to fully programmable protein catalysis
SL Lovelock, R Crawshaw, S Basler, C Levy, D Baker, D Hilvert, ...
Nature 606 (7912), 49-58, 2022
2392022
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
AJ Burke, SL Lovelock, A Frese, R Crawshaw, M Ortmayer, M Dunstan, ...
Nature 570 (7760), 219-223, 2019
1552019
A designed photoenzyme for enantioselective [2+ 2] cycloadditions
JS Trimble, R Crawshaw, FJ Hardy, CW Levy, MJB Brown, DE Fuerst, ...
Nature 611 (7937), 709-714, 2022
1222022
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction
R Crawshaw, AE Crossley, L Johannissen, AJ Burke, S Hay, C Levy, ...
Nature chemistry 14 (3), 313-320, 2022
702022
Design of heme enzymes with a tunable substrate binding pocket adjacent to an open metal coordination site
I Kalvet, M Ortmayer, J Zhao, R Crawshaw, NM Ennist, C Levy, A Roy, ...
Journal of the American Chemical Society 145 (26), 14307-14315, 2023
452023
An engineered cytidine deaminase for biocatalytic production of a key intermediate of the Covid-19 antiviral molnupiravir
AJ Burke, WR Birmingham, Y Zhuo, TW Thorpe, B Zucoloto da Costa, ...
Journal of the American Chemical Society 144 (9), 3761-3765, 2022
412022
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme
AE Hutton, J Foster, R Crawshaw, FJ Hardy, LO Johannissen, TM Lister, ...
Nature Communications 15 (1), 1956, 2024
142024
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme
A Crossley, R Crawshaw, F Hardy, L Johannissen, T Lister, E Gérard, ...
14*2023
A biocatalytic approach to a key intermediate for the synthesis of the COVID-19 experimental drug Molnupiravir
A Burke, W Birmingham, Y Zhuo, C BZd, R Crawshaw, T Thorpe, I Rowles, ...
52021
Engineering a Cytidine Aminotransferase for Biocatalytic Production of the Antiviral Molnupiravir
A Burke, W Birmingham, Y Zhuo, BZ da Costa, R Crawshaw, T Thorpe, ...
12021
Designing Enzymes for New Chemical Transformations
A Kohn, JS Trimble, R Crawshaw, AP Green
Elsevier, 2023
2023
A Designed Photoenzyme Promotes Enantioselective [2+ 2]-Cycloadditions via Triplet Energy Transfer
A Green, J Trimble, R Crawshaw, F Hardy, C Levy, M Brown, D Fuerst, ...
2022
Engineered Biocatalyst Permits Enantioselective Morita–Baylis–Hillman Reaction
R CRAWSHAW, AE CROSSLEY, L JOHANNISSEN, AJ BURKE, S HAY, ...
Science 374, 1612-1616, 2021
2021
Design and evolution of enzymes with new catalytic mechanisms
R Crawshaw
PQDT-UK & Ireland, 2021
2021
Engineering enzymes with non-canonical active site functionality
SL Lovelock, AJ Burke, R Crawshaw, M Ortmayer, M Dunstan, C Levy, ...
2019
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