The road to fully programmable protein catalysis SL Lovelock, R Crawshaw, S Basler, C Levy, D Baker, D Hilvert, ... Nature 606 (7912), 49-58, 2022 | 239 | 2022 |
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism AJ Burke, SL Lovelock, A Frese, R Crawshaw, M Ortmayer, M Dunstan, ... Nature 570 (7760), 219-223, 2019 | 155 | 2019 |
A designed photoenzyme for enantioselective [2+ 2] cycloadditions JS Trimble, R Crawshaw, FJ Hardy, CW Levy, MJB Brown, DE Fuerst, ... Nature 611 (7937), 709-714, 2022 | 122 | 2022 |
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction R Crawshaw, AE Crossley, L Johannissen, AJ Burke, S Hay, C Levy, ... Nature chemistry 14 (3), 313-320, 2022 | 70 | 2022 |
Design of heme enzymes with a tunable substrate binding pocket adjacent to an open metal coordination site I Kalvet, M Ortmayer, J Zhao, R Crawshaw, NM Ennist, C Levy, A Roy, ... Journal of the American Chemical Society 145 (26), 14307-14315, 2023 | 45 | 2023 |
An engineered cytidine deaminase for biocatalytic production of a key intermediate of the Covid-19 antiviral molnupiravir AJ Burke, WR Birmingham, Y Zhuo, TW Thorpe, B Zucoloto da Costa, ... Journal of the American Chemical Society 144 (9), 3761-3765, 2022 | 41 | 2022 |
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme AE Hutton, J Foster, R Crawshaw, FJ Hardy, LO Johannissen, TM Lister, ... Nature Communications 15 (1), 1956, 2024 | 14 | 2024 |
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme A Crossley, R Crawshaw, F Hardy, L Johannissen, T Lister, E Gérard, ... | 14* | 2023 |
A biocatalytic approach to a key intermediate for the synthesis of the COVID-19 experimental drug Molnupiravir A Burke, W Birmingham, Y Zhuo, C BZd, R Crawshaw, T Thorpe, I Rowles, ... | 5 | 2021 |
Engineering a Cytidine Aminotransferase for Biocatalytic Production of the Antiviral Molnupiravir A Burke, W Birmingham, Y Zhuo, BZ da Costa, R Crawshaw, T Thorpe, ... | 1 | 2021 |
Designing Enzymes for New Chemical Transformations A Kohn, JS Trimble, R Crawshaw, AP Green Elsevier, 2023 | | 2023 |
A Designed Photoenzyme Promotes Enantioselective [2+ 2]-Cycloadditions via Triplet Energy Transfer A Green, J Trimble, R Crawshaw, F Hardy, C Levy, M Brown, D Fuerst, ... | | 2022 |
Engineered Biocatalyst Permits Enantioselective Morita–Baylis–Hillman Reaction R CRAWSHAW, AE CROSSLEY, L JOHANNISSEN, AJ BURKE, S HAY, ... Science 374, 1612-1616, 2021 | | 2021 |
Design and evolution of enzymes with new catalytic mechanisms R Crawshaw PQDT-UK & Ireland, 2021 | | 2021 |
Engineering enzymes with non-canonical active site functionality SL Lovelock, AJ Burke, R Crawshaw, M Ortmayer, M Dunstan, C Levy, ... | | 2019 |