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Lei Wang
Lei Wang
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Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation
VD Nguyen, MJ Saaranen, AR Karala, AK Lappi, L Wang, IB Raykhel, ...
Journal of molecular biology 406 (3), 503-515, 2011
3292011
Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone
L Wang, X Wang, C Wang
Free Radical Biology and Medicine 83, 305-313, 2015
1812015
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
J Fang, J Yang, X Wu, G Zhang, T Li, X Wang, H Zhang, C Wang, GH Liu, ...
Aging cell 17 (4), e12765, 2018
1622018
Reconstitution of human Ero1-Lα/protein-disulfide isomerase oxidative folding pathway in vitro: position-dependent differences in role between the a and a′ domains of protein …
L Wang, S Li, A Sidhu, L Zhu, Y Liang, RB Freedman, C Wang
Journal of Biological Chemistry 284 (1), 199-206, 2009
1572009
Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a′
C Wang, J Yu, L Huo, L Wang, W Feng, C Wang
Journal of Biological Chemistry 287 (2), 1139-1149, 2012
1552012
Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis
X Wu, L Zhang, Y Miao, J Yang, X Wang, C Wang, J Feng, L Wang
Redox biology 20, 46-59, 2019
1442019
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding
L Wang, L Zhang, Y Niu, R Sitia, C Wang
Antioxidants & redox signaling 20 (4), 545-556, 2014
1432014
Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia
Y Li, Y Zhang, L Wang, P Wang, Y Xue, X Li, X Qiao, X Zhang, T Xu, G Liu, ...
Autophagy 13 (7), 1145-1160, 2017
1022017
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress
J Yu, T Li, Y Liu, X Wang, J Zhang, X Wang, G Shi, J Lou, L Wang, ...
The EMBO journal 39 (10), e103841, 2020
882020
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy‐terminal tail
L Wang, L Wang, S Vavassori, S Li, H Ke, T Anelli, M Degano, R Ronzoni, ...
EMBO reports 9 (7), 642-647, 2008
862008
Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance
C Wang, S Chen, X Wang, L Wang, AK Wallis, RB Freedman, C Wang
Journal of Biological Chemistry 285 (35), 26788-26797, 2010
792010
A solvatochromic fluorescent probe reveals polarity heterogeneity upon protein aggregation in cells
W Wan, L Zeng, W Jin, X Chen, D Shen, Y Huang, M Wang, Y Bai, H Lyu, ...
Angewandte Chemie 133 (49), 26069-26075, 2021
742021
The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation
L Wang, L Zhu, C Wang
Biochemical Journal 434 (1), 113-121, 2011
662011
Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111
WC Xu, JZ Liang, C Li, ZX He, HY Yuan, BY Huang, XL Liu, B Tang, ...
Cell death & disease 9 (2), 67, 2018
632018
Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α)
L Zhang, Y Niu, L Zhu, J Fang, L Wang, C Wang
Journal of Biological Chemistry 289 (45), 31188-31199, 2014
602014
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α
J Zhang, Q Zhu, X Wang, J Yu, X Chen, J Wang, X Wang, J Xiao, C Wang, ...
The EMBO Journal 37 (14), e98699, 2018
472018
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum
L Wang, C Wang
Trends in biochemical sciences 48 (1), 40-52, 2023
462023
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer
Y Zhang, T Li, L Zhang, F Shangguan, G Shi, X Wu, Y Cui, X Wang, Y Liu, ...
EBioMedicine 41, 408-419, 2019
462019
Domain a’of protein disulfide isomerase plays key role in inhibiting α-synuclein fibril formation
H Cheng, L Wang, C Wang
Cell Stress and Chaperones 15 (4), 415-421, 2010
442010
SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases
P Liu, X Wang, Y Sun, H Zhao, F Cheng, J Wang, F Yang, J Hu, H Zhang, ...
Redox Biology 54, 102388, 2022
302022
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