| Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ... Neuron 99 (5), 925-940. e7, 2018 | 421 | 2018 |
| Stress granule assembly disrupts nucleocytoplasmic transport K Zhang, JG Daigle, KM Cunningham, AN Coyne, K Ruan, JC Grima, ... Cell 173 (4), 958-971. e17, 2018 | 409 | 2018 |
| Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis AN Coyne, BB Siddegowda, PS Estes, J Johannesmeyer, T Kovalik, ... Journal of Neuroscience 34 (48), 15962-15974, 2014 | 180 | 2014 |
| CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ... Neuron 104 (5), 885-898. e8, 2019 | 135 | 2019 |
| G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD AN Coyne, BL Zaepfel, L Hayes, B Fitchman, Y Salzberg, EC Luo, ... Neuron 107 (6), 1124-1140. e11, 2020 | 133 | 2020 |
| Endocytosis regulates TDP-43 toxicity and turnover G Liu, AN Coyne, F Pei, S Vaughan, M Chaung, DC Zarnescu, JR Buchan Nature communications 8 (1), 2092, 2017 | 123 | 2017 |
| Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines EG Baxi, T Thompson, J Li, JA Kaye, RG Lim, J Wu, D Ramamoorthy, ... Nature neuroscience 25 (2), 226-237, 2022 | 114 | 2022 |
| Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS AN Coyne, I Lorenzini, CC Chou, M Torvund, RS Rogers, A Starr, ... Cell reports 21 (1), 110-125, 2017 | 110 | 2017 |
| Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS AN Coyne, V Baskerville, BL Zaepfel, DW Dickson, F Rigo, F Bennett, ... Science translational medicine 13 (604), eabe1923, 2021 | 104 | 2021 |
| Antibody therapy targeting RAN proteins rescues C9 ALS/FTD phenotypes in C9orf72 mouse model L Nguyen, F Montrasio, A Pattamatta, SK Tusi, O Bardhi, KD Meyer, ... Neuron 105 (4), 645-662. e11, 2020 | 101 | 2020 |
| Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation AN Coyne, SB Yamada, BB Siddegowda, PS Estes, BL Zaepfel, ... Human molecular genetics 24 (24), 6886-6898, 2015 | 94 | 2015 |
| Nuclear pore complexes—a doorway to neural injury in neurodegeneration AN Coyne, JD Rothstein Nature Reviews Neurology 18 (6), 348-362, 2022 | 76 | 2022 |
| Failure to deliver and translate—new insights into RNA dysregulation in ALS AN Coyne, BL Zaepfel, DC Zarnescu Frontiers in cellular neuroscience 11, 243, 2017 | 67 | 2017 |
| Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models JA Bush, H Aikawa, R Fuerst, Y Li, A Ursu, SM Meyer, RI Benhamou, ... Science translational medicine 13 (617), eabd5991, 2021 | 58 | 2021 |
| An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients H Phatnani, J Kwan, D Sareen, JR Broach, Z Simmons, X Arcila-Londono, ... Iscience 24 (11), 2021 | 36 | 2021 |
| UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction BL Zaepfel, Z Zhang, K Maulding, AN Coyne, W Cheng, LR Hayes, ... Cell reports 34 (13), 2021 | 31 | 2021 |
| Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ... Neuron 101 (2), 349, 2019 | 26 | 2019 |
| Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism K Zhang, AN Coyne, TE Lloyd Brain research 1693, 109-120, 2018 | 23 | 2018 |
| SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis V Baskerville, S Rapuri, E Mehlhop, AN Coyne Brain 147 (1), 109-121, 2024 | 19 | 2024 |
| The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei AN Coyne, JD Rothstein Acta neuropathologica communications 9 (1), 127, 2021 | 16 | 2021 |
