| Rational discovery of molecular glue degraders via scalable chemical profiling C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ... Nature chemical biology 16 (11), 1199-1207, 2020 | 281 | 2020 |
| 1, 6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities R Düster, IH Kaltheuner, M Schmitz, M Geyer Journal of Biological Chemistry 296, 2021 | 142 | 2021 |
| Discovery and resistance mechanism of a selective CDK12 degrader B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ... Nature chemical biology 17 (6), 675-683, 2021 | 102 | 2021 |
| P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection LM Jenster, KE Lange, S Normann, A vom Hemdt, JD Wuerth, ... Journal of Experimental Medicine 220 (1), e20220837, 2022 | 79 | 2022 |
| Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription JK Rimel, ZC Poss, B Erickson, ZL Maas, CC Ebmeier, JL Johnson, ... Genes & development 34 (21-22), 1452-1473, 2020 | 71 | 2020 |
| LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding KU Ludwig, RM Schmithausen, D Li, ML Jacobs, R Hollstein, ... Nature biotechnology 39 (12), 1556-1562, 2021 | 68 | 2021 |
| Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation K Baßler, W Fujii, TS Kapellos, E Dudkin, N Reusch, A Horne, B Reiz, ... Frontiers in immunology 13, 917232, 2022 | 43* | 2022 |
| Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma B Jiang, J Jiang, IH Kaltheuner, AB Iniguez, K Anand, FM Ferguson, ... European Journal of Medicinal Chemistry 221, 113481, 2021 | 40 | 2021 |
| Oncogenic CDK13 mutations impede nuclear RNA surveillance ML Insco, BJ Abraham, SJ Dubbury, IH Kaltheuner, S Dust, C Wu, ... Science 380 (6642), eabn7625, 2023 | 25 | 2023 |
| Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation IH Kaltheuner, K Anand, J Moecking, R Düster, J Wang, NS Gray, ... Nature communications 12 (1), 6607, 2021 | 24 | 2021 |
| The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation M Schmitz, IH Kaltheuner, K Anand, R Düster, J Moecking, A Monastyrskyi, ... Journal of Biological Chemistry 300 (1), 2024 | 3 | 2024 |
| The MYCN/Aurora-A complex is a cyclin activating kinase for CDK12 M Mueller, L Eing, L Uhl, M Schmitz, I Kaneva, DP Byrne, D Fleischhauer, ... bioRxiv, 2025.01. 15.633177, 2025 | | 2025 |
| Structural and Functional Characterization of Human Transcription-regulating Kinases IH Kaltheuner Universitäts-und Landesbibliothek Bonn, 2024 | | 2024 |
