Mechanisms of dysfunction in the aging vasculature and role in age-related disease AJ Donato, DR Machin, LA Lesniewski Circulation research 123 (7), 825-848, 2018 | 562 | 2018 |
Cellular and molecular biology of aging endothelial cells AJ Donato, RG Morgan, AE Walker, LA Lesniewski Journal of molecular and cellular cardiology 89, 122-135, 2015 | 554 | 2015 |
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and … JR Durrant, DR Seals, ML Connell, MJ Russell, BR Lawson, BJ Folian, ... The Journal of physiology 587 (13), 3271-3285, 2009 | 294 | 2009 |
Nuclear factor-κB activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans GL Pierce, LA Lesniewski, BR Lawson, SD Beske, DR Seals Circulation 119 (9), 1284-1292, 2009 | 292 | 2009 |
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans AJ Donato, KA Magerko, BR Lawson, JR Durrant, LA Lesniewski, ... The Journal of physiology 589 (18), 4545-4554, 2011 | 286 | 2011 |
Arterial stiffening with ageing is associated with transforming growth factor‐β1‐related changes in adventitial collagen: reversal by aerobic exercise BS Fleenor, KD Marshall, JR Durrant, LA Lesniewski, DR Seals The Journal of physiology 588 (20), 3971-3982, 2010 | 273 | 2010 |
Habitual exercise and vascular ageing DR Seals, AE Walker, GL Pierce, LA Lesniewski The Journal of physiology 587 (23), 5541-5549, 2009 | 249 | 2009 |
Mechanisms and consequences of endothelial cell senescence SI Bloom, MT Islam, LA Lesniewski, AJ Donato Nature Reviews Cardiology 20 (1), 38-51, 2023 | 208 | 2023 |
Life‐long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice AJ Donato, AE Walker, KA Magerko, RC Bramwell, AD Black, GD Henson, ... Aging cell 12 (5), 772-783, 2013 | 195 | 2013 |
Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation CC Gibson, W Zhu, CT Davis, JA Bowman-Kirigin, AC Chan, J Ling, ... Circulation 131 (3), 289-299, 2015 | 181 | 2015 |
Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress C Rippe, L Lesniewski, M Connell, T LaRocca, A Donato, D Seals Aging cell 9 (3), 304-312, 2010 | 178 | 2010 |
Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways LA Lesniewski, DR Seals, AE Walker, GD Henson, MW Blimline, DW Trott, ... Aging cell 16 (1), 17-26, 2017 | 151 | 2017 |
Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles J Muller-Delp, SA Spier, MW Ramsey, LA Lesniewski, A Papadopoulos, ... American Journal of Physiology-Heart and Circulatory Physiology 282 (5 …, 2002 | 150 | 2002 |
Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance LA Lesniewski, SE Hosch, JG Neels, C de Luca, M Pashmforoush, ... Nature medicine 13 (4), 455-462, 2007 | 143 | 2007 |
Aerobic exercise reverses arterial inflammation with aging in mice LA Lesniewski, JR Durrant, ML Connell, GD Henson, AD Black, ... American Journal of Physiology-Heart and Circulatory Physiology 301 (3 …, 2011 | 141 | 2011 |
The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles AJ Donato, LA Lesniewski, MD Delp Cardiovascular research 66 (2), 393-401, 2005 | 123 | 2005 |
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age MT Islam, E Tuday, S Allen, J Kim, DW Trott, WL Holland, AJ Donato, ... Aging Cell 22 (2), e13767, 2023 | 119 | 2023 |
Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries RG Morgan, SJ Ives, LA Lesniewski, RM Cawthon, RHI Andtbacka, ... American Journal of Physiology-Heart and Circulatory Physiology 305 (2 …, 2013 | 119 | 2013 |
Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism MK Wilkerson, LA Lesniewski, EM Golding, RM Bryan Jr, A Amin, ... American Journal of Physiology-Heart and Circulatory Physiology 288 (4 …, 2005 | 114 | 2005 |
B6D2F1 Mice Are a Suitable Model of Oxidative Stress–Mediated Impaired Endothelium-Dependent Dilation With Aging LA Lesniewski, ML Connell, JR Durrant, BJ Folian, MC Anderson, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2009 | 111 | 2009 |