| C9ORF72-ALS/FTD-associated poly (GR) binds Atp5a1 and compromises mitochondrial function in vivo SY Choi, R Lopez-Gonzalez, G Krishnan, HL Phillips, AN Li, WW Seeley, ... Nature neuroscience 22 (6), 851-862, 2019 | 229 | 2019 |
| Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD R Lopez-Gonzalez, D Yang, M Pribadi, TS Kim, G Krishnan, SY Choi, ... Proceedings of the National Academy of Sciences 116 (19), 9628-9633, 2019 | 82 | 2019 |
| Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation G Krishnan, N Chatterjee Glia 60 (11), 1629-1645, 2012 | 73 | 2012 |
| Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD Y Yuva-Aydemir, S Almeida, G Krishnan, TF Gendron, FB Gao Nature communications 10 (1), 5466, 2019 | 55 | 2019 |
| PIKFYVE inhibition mitigates disease in models of diverse forms of ALS ST Hung, GR Linares, WH Chang, Y Eoh, G Krishnan, S Mendonca, ... Cell 186 (4), 786-802. e28, 2023 | 53 | 2023 |
| CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro KE Meijboom, A Abdallah, NP Fordham, H Nagase, T Rodriguez, C Kraus, ... Nature communications 13 (1), 6286, 2022 | 48 | 2022 |
| Altered MICOS morphology and mitochondrial ion homeostasis contribute to poly (GR) toxicity associated with C9-ALS/FTD S Li, Z Wu, Y Li, I Tantray, D De Stefani, A Mattarei, G Krishnan, FB Gao, ... Cell reports 32 (5), 2020 | 42 | 2020 |
| A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, ... Nature communications 12 (1), 6025, 2021 | 38 | 2021 |
| CRISPR deletion of the C9ORF72 promoter in ALS/FTD patient motor neurons abolishes production of dipeptide repeat proteins and rescues neurodegeneration G Krishnan, Y Zhang, Y Gu, MW Kankel, FB Gao, S Almeida Acta neuropathologica 140, 81-84, 2020 | 37 | 2020 |
| Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD G Krishnan, D Raitcheva, D Bartlett, M Prudencio, DM McKenna-Yasek, ... Nature communications 13 (1), 2799, 2022 | 36 | 2022 |
| Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells S Almeida, G Krishnan, M Rushe, Y Gu, MW Kankel, FB Gao Acta Neuropathologica 138, 1099-1101, 2019 | 33 | 2019 |
| Targeted expression of suicide gene by tissue-specific promoter and microRNA regulation for cancer gene therapy R Danda, G Krishnan, K Ganapathy, UM Krishnan, K Vikas, S Elchuri, ... PloS one 8 (12), e83398, 2013 | 33 | 2013 |
| Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity G Krishnan, N Chatterjee Molecular and Cellular Neuroscience 59, 10-23, 2014 | 28 | 2014 |
| Anandamide rescues retinal barrier properties in Müller glia through nitric oxide regulation G Krishnan, N Chatterjee Neuroscience 284, 536-545, 2015 | 17 | 2015 |
| Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly (GR)-induced neurotoxicity in C9ORF72-ALS/FTD S Lee, YW Jun, GR Linares, B Butler, Y Yuva-Adyemir, J Moore, ... Neuron 111 (9), 1381-1390. e6, 2023 | 15 | 2023 |
| Detergent resistant membrane fractions are involved in calcium signaling in Müller glial cells of retina G Krishnan, N Chatterjee The International Journal of Biochemistry & Cell Biology 45 (8), 1758-1766, 2013 | 9 | 2013 |
| Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in R Lopez-Gonzalez, D Yang, M Pribadi, TS Kim, G Krishnan, SY Choi, ... C9ORF72, 0 | 9 | |
| Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA G Krishnan, N Chatterjee Scientific reports 5 (1), 9887, 2015 | 8 | 2015 |
| Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons Y Sonobe, S Lee, G Krishnan, Y Gu, DY Kwon, FB Gao, RP Roos, ... Elife 12, e83189, 2023 | 6 | 2023 |
| Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons D Dong, Z Zhang, Y Li, MJ Latallo, S Wang, B Nelson, R Wu, G Krishnan, ... Science signaling 17 (848), eadl1030, 2024 | 2 | 2024 |