| Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells R Lin, Z Zhang, L Chen, Y Zhou, P Zou, C Feng, L Wang, G Liang Cancer letters 381 (1), 165-175, 2016 | 292 | 2016 |
| Recent progress of small-molecule epidermal growth factor receptor (EGFR) inhibitors against C797S resistance in non-small-cell lung cancer: miniperspective L Chen, W Fu, L Zheng, Z Liu, G Liang Journal of medicinal chemistry 61 (10), 4290-4300, 2017 | 142 | 2017 |
| Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer P Zou, Y Xia, J Ji, W Chen, J Zhang, X Chen, V Rajamanickam, G Chen, ... Cancer letters 375 (1), 114-126, 2016 | 134 | 2016 |
| Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling L Chen, L Zheng, P Chen, G Liang Journal of medicinal chemistry 63 (22), 13316-13329, 2020 | 100 | 2020 |
| EGFR inhibition blocks palmitic acid-induced inflammation in cardiomyocytes and prevents hyperlipidemia-induced cardiac injury in mice W Li, Q Fang, P Zhong, L Chen, L Wang, Y Zhang, J Wang, X Li, Y Wang, ... Scientific reports 6 (1), 24580, 2016 | 78 | 2016 |
| New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity Y Zhang, Z Liu, J Wu, B Bai, H Chen, Z Xiao, L Chen, Y Zhao, H Lum, ... European Journal of Medicinal Chemistry 148, 291-305, 2018 | 73 | 2018 |
| Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats H Zhu, T Xu, C Qiu, B Wu, Y Zhang, L Chen, Q Xia, C Li, B Zhou, Z Liu, ... European Journal of Medicinal Chemistry 121, 181-193, 2016 | 60 | 2016 |
| Design, synthesis, and biological evaluation of novel quinazoline derivatives as anti‐inflammatory agents against lipopolysaccharide‐induced acute lung injury in rats J Hu, Y Zhang, L Dong, Z Wang, L Chen, D Liang, D Shi, X Shan, G Liang Chemical Biology & Drug Design 85 (6), 672-684, 2015 | 60 | 2015 |
| Fibroblast growth factor receptor fusions in cancer: opportunities and challenges L Chen, Y Zhang, L Yin, B Cai, P Huang, X Li, G Liang Journal of Experimental & Clinical Cancer Research 40, 1-15, 2021 | 54 | 2021 |
| Recent progress in the discovery of myeloid differentiation 2 (MD2) modulators for inflammatory diseases L Chen, W Fu, L Zheng, Y Wang, G Liang Drug Discovery Today 23 (6), 1187-1202, 2018 | 52 | 2018 |
| Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury L Chen, H Chen, P Chen, W Zhang, C Wu, C Sun, W Luo, L Zheng, Z Liu, ... European Journal of Medicinal Chemistry 161, 22-38, 2019 | 50 | 2019 |
| Discovery of 3-(Indol-5-yl)-indazole derivatives as novel myeloid differentiation protein 2/toll-like receptor 4 antagonists for treatment of acute lung injury Z Liu, L Chen, P Yu, Y Zhang, B Fang, C Wu, W Luo, X Chen, C Li, ... Journal of Medicinal Chemistry 62 (11), 5453-5469, 2019 | 49 | 2019 |
| Structural basis for FGF hormone signalling L Chen, L Fu, J Sun, Z Huang, M Fang, A Zinkle, X Liu, J Lu, Z Pan, ... Nature 618 (7966), 862-870, 2023 | 45 | 2023 |
| Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases H Xu, J Chen, P Chen, W Li, J Shao, S Hong, Y Wang, L Chen, W Luo, ... Acta Pharmaceutica Sinica B 13 (2), 678-693, 2023 | 45 | 2023 |
| Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury L Chen, Y Jin, H Chen, C Sun, W Fu, L Zheng, M Lu, P Chen, G Chen, ... European Journal of Medicinal Chemistry 143, 361-375, 2018 | 44 | 2018 |
| Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2 W Fu, L Chen, Z Wang, C Zhao, G Chen, X Liu, Y Dai, Y Cai, C Li, J Zhou, ... Drug Design, Development and Therapy, 455-463, 2016 | 37 | 2016 |
| Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88‐dependent inflammation W Luo, K Lin, J Hua, J Han, Q Zhang, L Chen, ZA Khan, G Wu, Y Wang, ... Advanced Science 9 (31), 2202590, 2022 | 35 | 2022 |
| Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation L Chen, WM Marsiglia, H Chen, J Katigbak, H Erdjument-Bromage, ... Nature chemical biology 16 (3), 267-277, 2020 | 35 | 2020 |
| Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2‐a]pyrimidine Derivatives with Anti‐inflammatory Activity in Acute Lung Injury L Chen, Y Jin, W Fu, S Xiao, C Feng, B Fang, Y Gu, C Li, Y Zhao, Z Liu, ... ChemMedChem 12 (13), 1022-1032, 2017 | 34 | 2017 |
| Structure-based design and synthesis of 2, 4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC L Chen, W Fu, C Feng, R Qu, L Tong, L Zheng, B Fang, Y Qiu, J Hu, Y Cai, ... European Journal of Medicinal Chemistry 140, 510-527, 2017 | 28 | 2017 |
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