Alessio Ciulli

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Katkıda bulunan yazarlar

Andrea TestaTRIMTECH THERAPEUTICStrimtechtherapeutics.com üzerinde doğrulanmış e-posta adresine sahip
Scott J. HughesUniversity of Dundeedundee.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Chiara ManiaciUniversity of Dundeedundee.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Tom L BlundellEmeritus Professor of Biochemistry, University of Cambridgecam.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Xavier LucasComputational medicinal chemist at Monte Rosa Therapeutics, Baselmonterosatx.com üzerinde doğrulanmış e-posta adresine sahip
Dennis BuckleyNIBRnovartis.com üzerinde doğrulanmış e-posta adresine sahip
Craig CrewsYale Universityyale.edu üzerinde doğrulanmış e-posta adresine sahip
William L. JorgensenSterling Professor of Chemistry, Yale Universityyale.edu üzerinde doğrulanmış e-posta adresine sahip
Sonia RochaDepartment of Biochemistry, Cell and Systems Biology, ISMIB, University of Liverpoolliverpool.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Carles GaldeanoSerra Hunter Lecturer Professor at University of Barcelonaub.edu üzerinde doğrulanmış e-posta adresine sahip
William FarnabyUniversity of Dundeedundee.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Danette DanielsGroup Leader, Promega Corporationpromega.com üzerinde doğrulanmış e-posta adresine sahip
Dario AlessiMRC Protein Phosphorylation and Ubiquitylation Units, University of Dundeedundee.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Matthias BaudUniversity of Southamptonsoton.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Prof. Alison G. SmithDept of Plant Sciences, University of Cambridgecam.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Panagis FilippakopoulosAssociate Professor, Oxford Universitysgc.ox.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Fleur M. FergusonUniversity of California, San Diegoucsd.edu üzerinde doğrulanmış e-posta adresine sahip
Oleg FedorovUniversity of Oxfordcmd.ox.ac.uk üzerinde doğrulanmış e-posta adresine sahip
Georg E WinterPrincipal Investigator at CeMM, Viennacemm.oeaw.ac.at üzerinde doğrulanmış e-posta adresine sahip
Dr Ola EpemoluPrincipal Research Scientist in In vitro/In vivo DMPK -CRLcrl.com üzerinde doğrulanmış e-posta adresine sahip

Takip et

Alessio Ciulli

Professor, University of Dundee

dundee.ac.uk üzerinde doğrulanmış e-posta adresine sahip - Ana Sayfa

Chemical Biology Structural Biology Medicinal Chemistry Drug Discovery Targeted Protein Degradation


Başlık Alıntılara göre sırala Yıla göre sırala Başlığa göre sırala	Alıntı yapanlar Alıntı yapanlar	Yıl
Structural basis of PROTAC cooperative recognition for selective protein degradation MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ... Nature chemical biology 13 (5), 514-521, 2017	1097	2017
Selective small molecule induced degradation of the BET bromodomain protein BRD4 M Zengerle, KH Chan, A Ciulli ACS chemical biology 10 (8), 1770-1777, 2015	1049	2015
Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction DL Buckley, I Van Molle, PC Gareiss, HS Tae, J Michel, DJ Noblin, ... Journal of the American Chemical Society 134 (10), 4465-4468, 2012	591	2012
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design W Farnaby, M Koegl, MJ Roy, C Whitworth, E Diers, N Trainor, D Zollman, ... Nature chemical biology 15 (7), 672-680, 2019	496	2019
Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the hypoxia … C Galdeano, MS Gadd, P Soares, S Scaffidi, I Van Molle, I Birced, ... Journal of Medicinal Chemistry 57 (20), 8657-8663, 2014	442	2014
Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α DL Buckley, JL Gustafson, I Van Molle, AG Roth, HS Tae, PC Gareiss, ... Angewandte Chemie (International Ed. in English) 51 (46), 11463, 2012	354	2012
Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based … V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ... Journal of medicinal chemistry 62 (2), 699-726, 2018	319	2018
SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate MJ Roy, S Winkler, SJ Hughes, C Whitworth, M Galant, W Farnaby, ... ACS chemical biology 14 (3), 361-368, 2019	297	2019
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ... Nature Communications 8 (1), 830, 2017	284	2017
E3 ligase ligands for PROTACs: how they were found and how to discover new ones T Ishida, A Ciulli SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (4), 484-502, 2021	270	2021
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation E Bulatov, A Ciulli Biochemical Journal 467 (3), 365-386, 2015	238	2015
Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1 … KH Chan, M Zengerle, A Testa, A Ciulli Journal of medicinal chemistry 61 (2), 504-513, 2018	230	2018
Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: hypoxia inducible factor 1α protein-protein interface I Van Molle, A Thomann, DL Buckley, EC So, S Lang, CM Crews, A Ciulli Chemistry & biology 19 (10), 1300-1312, 2012	227	2012
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition J Frost, C Galdeano, P Soares, MS Gadd, KM Grzes, L Ellis, O Epemolu, ... Nature communications 7 (1), 13312, 2016	223	2016
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders SJ Hughes, A Ciulli Essays in biochemistry 61 (5), 505-516, 2017	217	2017
Structure‐based design of a macrocyclic PROTAC A Testa, SJ Hughes, X Lucas, JE Wright, A Ciulli Angewandte Chemie 132 (4), 1744-1751, 2020	209	2020
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase CM Crews, D Buckley, A Ciulli, W Jorgensen, PC Gareiss, I Van Molle, ... US Patent 10,730,862, 2020	193	2020
Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein–protein interactions TAF Cardote, A Ciulli ChemMedChem 11 (8), 787-794, 2016	190	2016
Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase This research was supported by the … AW Hung, HL Silvestre, S Wen, A Ciulli, TL Blundell, C Abell Angewandte Chemie-German Edition 121 (45), 8604, 2009	188	2009
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ... Nature chemical biology 17 (11), 1157–1167, 2021	178	2021

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