| Modulation of Akt kinase activity by binding to Hsp90 S Sato, N Fujita, T Tsuruo Proceedings of the National Academy of Sciences 97 (20), 10832-10837, 2000 | 1251 | 2000 |
| The ALK inhibitor ceritinib overcomes crizotinib resistance in non–small cell lung cancer L Friboulet, N Li, R Katayama, CC Lee, JF Gainor, AS Crystal, ... Cancer discovery 4 (6), 662-673, 2014 | 940 | 2014 |
| Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal T Tsuruo, M Naito, A Tomida, N Fujita, T Mashima, H Sakamoto, N Haga Cancer science 94 (1), 15-21, 2003 | 696 | 2003 |
| Akt-dependent phosphorylation of p27Kip1promotes binding to 14-3-3 and cytoplasmic localization N Fujita, S Sato, K Katayama, T Tsuruo Journal of Biological Chemistry 277 (32), 28706-28713, 2002 | 456 | 2002 |
| Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO … J Fontana, D Fulton, Y Chen, TA Fairchild, TJ McCabe, N Fujita, T Tsuruo, ... Circulation research 90 (8), 866-873, 2002 | 454 | 2002 |
| Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow M Shimonaka, K Katagiri, T Nakayama, N Fujita, T Tsuruo, O Yoshie, ... The Journal of cell biology 161 (2), 417-427, 2003 | 446 | 2003 |
| Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer K Uchibori, N Inase, M Araki, M Kamada, S Sato, Y Okuno, N Fujita, ... Nature communications 8 (1), 14768, 2017 | 412 | 2017 |
| Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels D Morishita, R Katayama, K Sekimizu, T Tsuruo, N Fujita Cancer research 68 (13), 5076-5085, 2008 | 356 | 2008 |
| Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib R Katayama, L Friboulet, S Koike, EL Lockerman, TM Khan, JF Gainor, ... Clinical cancer research 20 (22), 5686-5696, 2014 | 335 | 2014 |
| Molecular identification of Aggrus/T1α as a platelet aggregation-inducing factor expressed in colorectal tumors Y Kato, N Fujita, A Kunita, S Sato, M Kaneko, M Osawa, T Tsuruo Journal of Biological Chemistry 278 (51), 51599-51605, 2003 | 333 | 2003 |
| Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis Y Zhang, N Fujita, T Tsuruo Oncogene 18 (5), 1131-1138, 1999 | 327 | 1999 |
| Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis T Mashima, M Naito, N Fujita, K Noguchi, T Tsuruo Biochemical and biophysical research communications 217 (3), 1185-1192, 1995 | 284 | 1995 |
| Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine) S Sato, N Fujita, T Tsuruo Oncogene 21 (11), 1727-1738, 2002 | 273 | 2002 |
| Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1 N Fujita, S Sato, A Ishida, T Tsuruo Journal of Biological Chemistry 277 (12), 10346-10353, 2002 | 257 | 2002 |
| Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma Y Kato, M Kaneko, M Sata, N Fujita, T Tsuruo, M Osawa Tumor Biology 26 (4), 195-200, 2005 | 255 | 2005 |
| Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization N Fujita, S Sato, T Tsuruo Journal of Biological Chemistry 278 (49), 49254-49260, 2003 | 251 | 2003 |
| Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer B Gong, K Kiyotani, S Sakata, S Nagano, S Kumehara, S Baba, B Besse, ... Journal of Experimental Medicine 216 (4), 982-1000, 2019 | 243 | 2019 |
| Binding and phosphorylation of par-4 by akt is essential for cancer cell survival A Goswami, R Burikhanov, A de Thonel, N Fujita, M Goswami, Y Zhao, ... Molecular cell 20 (1), 33-44, 2005 | 236 | 2005 |
| Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2 S Takagi, S Sato, T Oh-hara, M Takami, S Koike, Y Mishima, K Hatake, ... PloS one 8 (8), e73609, 2013 | 222 | 2013 |
| Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition R Katayama, A Aoyama, T Yamori, J Qi, T Oh-hara, Y Song, JA Engelman, ... Cancer research 73 (10), 3087-3096, 2013 | 220 | 2013 |
