| Combined VEGF and PD-L1 blockade displays synergistic treatment effects in an autochthonous mouse model of small cell lung cancer L Meder, P Schuldt, M Thelen, A Schmitt, F Dietlein, S Klein, S Borchmann, ... Cancer research 78 (15), 4270-4281, 2018 | 157 | 2018 |
| Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors J Fassunke, F Müller, M Keul, S Michels, MA Dammert, A Schmitt, ... Nature communications 9 (1), 4655, 2018 | 141 | 2018 |
| Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma K Shigeta, A Matsui, H Kikuchi, S Klein, E Mamessier, IX Chen, S Aoki, ... Journal for immunotherapy of cancer 8 (2), 2020 | 118 | 2020 |
| MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer MA Dammert, J Brägelmann, RR Olsen, S Böhm, N Monhasery, ... Nature communications 10 (1), 3485, 2019 | 82 | 2019 |
| MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I J Brägelmann, C Lorenz, S Borchmann, K Nishii, J Wegner, L Meder, ... Nature communications 12 (1), 5505, 2021 | 52 | 2021 |
| Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma S Aoki, K Inoue, S Klein, S Halvorsen, J Chen, A Matsui, MR Nikmaneshi, ... Gut 71 (1), 185-193, 2022 | 50 | 2022 |
| Deep learning predicts HPV association in oropharyngeal squamous cell carcinomas and identifies patients with a favorable prognosis using regular H&E stains S Klein, A Quaas, J Quantius, H Löser, J Meinel, M Peifer, S Wagner, ... Clinical Cancer Research 27 (4), 1131-1138, 2021 | 47 | 2021 |
| Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance S Grasse, M Lienhard, S Frese, M Kerick, A Steinbach, C Grimm, ... Genome medicine 10 (1), 1-16, 2018 | 46 | 2018 |
| The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage K Shostak, Z Jiang, B Charloteaux, A Mayer, Y Habraken, L Tharun, ... Nature Communications 11 (1), 1270, 2020 | 42 | 2020 |
| Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600E/K mutated malignant melanomas S Klein, C Mauch, K Brinker, KW Noh, S Knez, R Büttner, A Quaas, ... Scientific Reports 11 (1), 1834, 2021 | 38 | 2021 |
| Deep learning for sensitive detection of Helicobacter Pylori in gastric biopsies S Klein, J Gildenblat, MA Ihle, S Merkelbach-Bruse, KW Noh, M Peifer, ... BMC gastroenterology 20 (1), 1-11, 2020 | 38 | 2020 |
| An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities R Flümann, T Rehkämper, P Nieper, P Pfeiffer, A Holzem, S Klein, ... Blood cancer discovery 2 (1), 70-91, 2021 | 36 | 2021 |
| Integrative analysis of pleomorphic dermal sarcomas reveals fibroblastic differentiation and susceptibility to immunotherapy S Klein, A Quaas, KW Noh, M Cartolano, N Abedpour, C Mauch, ... Clinical Cancer Research 26 (21), 5638-5645, 2020 | 35 | 2020 |
| Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy M Thelen, K Wennhold, J Lehmann, M Garcia-Marquez, S Klein, ... npj precision oncology 5 (1), 52, 2021 | 34 | 2021 |
| Potential circulating biomarkers of recurrence after hepatic resection or liver transplantation in hepatocellular carcinoma patients DG Duda, SO Dima, D Cucu, A Sorop, S Klein, M Ancukiewicz, S Kitahara, ... Cancers 12 (5), 1275, 2020 | 33 | 2020 |
| First report on two cases of pleomorphic dermal sarcoma successfully treated with immune checkpoint inhibitors S Klein, OD Persa, C Mauch, KW Noh, R Pappesch, S Wagener-Ryczek, ... Oncoimmunology 8 (12), e1665977, 2019 | 30 | 2019 |
| Immune-phenotyping of pleomorphic dermal sarcomas suggests this entity as a potential candidate for immunotherapy S Klein, C Mauch, S Wagener-Ryczek, M Schoemmel, R Buettner, ... Cancer Immunology, Immunotherapy 68, 973-982, 2019 | 29 | 2019 |
| Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma A Quaas, A Pamuk, S Klein, J Quantius, J Rehkaemper, AG Barutcu, ... Gastric Cancer 24 (6), 1213-1226, 2021 | 27 | 2021 |
| Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization D Chen, I Nemazanyy, O Peulen, K Shostak, X Xu, SC Tang, C Wathieu, ... The EMBO Journal 41 (18), e109353, 2022 | 23 | 2022 |
| LSD1 inhibition attenuates tumor growth by disrupting PLK1 mitotic pathway PS Dalvi, IF Macheleidt, SY Lim, S Meemboor, M Müller, ... Molecular Cancer Research 17 (6), 1326-1337, 2019 | 22 | 2019 |