| Metabolic fate of glucose in purified islet cells: glucose-regulated anaplerosis in β cells F Schuit, A De Vos, S Farfari, K Moens, D Pipeleers, T Brun, M Prentki Journal of Biological Chemistry 272 (30), 18572-18579, 1997 | 531 | 1997 |
| Mitochondrial dysfunction in pancreatic β cells S Supale, N Li, T Brun, P Maechler Trends in Endocrinology & Metabolism 23 (9), 477-487, 2012 | 316 | 2012 |
| MAFA controls genes implicated in insulin biosynthesis and secretion H Wang, T Brun, K Kataoka, AJ Sharma, CB Wollheim Diabetologia 50, 348-358, 2007 | 259 | 2007 |
| Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1 VM Schwitzgebel, A Mamin, T Brun, B Ritz-Laser, M Zaiko, A Maret, ... The Journal of Clinical Endocrinology & Metabolism 88 (9), 4398-4406, 2003 | 216 | 2003 |
| Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism L Vetterli, T Brun, L Giovannoni, D Bosco, P Maechler Journal of Biological Chemistry 286 (8), 6049-6060, 2011 | 200 | 2011 |
| The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets T Brun, I Franklin, L St-Onge, A Biason-Lauber, EJ Schoenle, ... The Journal of cell biology 167 (6), 1123-1135, 2004 | 197 | 2004 |
| Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. E Roche, S Farfari, LA Witters, F Assimacopoulos-Jeannet, S Thumelin, ... Diabetes 47 (7), 1086-1094, 1998 | 188 | 1998 |
| Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic β-cell nutrient signaling T Brun, E Roche, F Assimacopoulos-Jeannet, BE Corkey, KH Kim, ... Diabetes 45 (2), 190-198, 1996 | 181 | 1996 |
| Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). T Brun, E Roche, KH Kim, M Prentki Journal of Biological Chemistry 268 (25), 18905-18911, 1993 | 172 | 1993 |
| Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic β-cell line INS-1 T Brun, F Assimacopoulos-Jeannet, BE Corkey, M Prentki Diabetes 46 (3), 393-400, 1997 | 148 | 1997 |
| NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion N Li, B Li, T Brun, C Deffert-Delbouille, Z Mahiout, Y Daali, XJ Ma, ... Diabetes 61 (11), 2842-2850, 2012 | 133 | 2012 |
| Increased fat intake during lactation modifies hypothalamic-pituitary-adrenal responsiveness in developing rat pups: a possible role for leptin G Trottier, KG Koski, T Brun, DJ Toufexis, D Richard, CD Walker Endocrinology 139 (9), 3704-3711, 1998 | 132 | 1998 |
| Transient oxidative stress damages mitochondrial machinery inducing persistent β-cell dysfunction N Li, T Brun, M Cnop, DA Cunha, DL Eizirik, P Maechler Journal of Biological Chemistry 284 (35), 23602-23612, 2009 | 118 | 2009 |
| Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets BR Gauthier, T Brun, EJ Sarret, H Ishihara, O Schaad, P Descombes, ... Journal of Biological Chemistry 279 (30), 31121-31130, 2004 | 100 | 2004 |
| Role of mitochondria in β-cell function and dysfunction P Maechler, N Li, M Casimir, L Vetterli, F Frigerio, T Brun The Islets of Langerhans, 193-216, 2010 | 97 | 2010 |
| Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity A Biason-Lauber, B Boehm, M Lang-Muritano, BR Gauthier, T Brun, ... Diabetologia 48, 900-905, 2005 | 89 | 2005 |
| A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease. T Brun, BR Gauthier Journal of molecular endocrinology 40 (2), 37-45, 2008 | 73 | 2008 |
| The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 T Brun, KHH He, R Lupi, B Boehm, A Wojtusciszyn, N Sauter, M Donath, ... Human molecular genetics 17 (4), 478-489, 2008 | 72 | 2008 |
| In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice KHH He, PI Lorenzo, T Brun, CM Jimenez Moreno, D Aeberhard, ... Diabetes 60 (6), 1705-1715, 2011 | 66 | 2011 |
| Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes DA Glauser, T Brun, BR Gauthier, W Schlegel BMC molecular biology 8, 1-15, 2007 | 66 | 2007 |
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