| Uridine depletion and chemical modification increase Cas9 mRNA activity and reduce immunogenicity without HPLC purification S Vaidyanathan, KT Azizian, AKMA Haque, JM Henderson, A Hendel, ... Molecular Therapy-Nucleic Acids 12, 530-542, 2018 | 262 | 2018 |
| Highly efficient and marker-free genome editing of human pluripotent stem cells by CRISPR-Cas9 RNP and AAV6 donor-mediated homologous recombination RM Martin, K Ikeda, MK Cromer, N Uchida, T Nishimura, R Romano, ... Cell stem cell 24 (5), 821-828. e5, 2019 | 190 | 2019 |
| High-efficiency, selection-free gene repair in airway stem cells from cystic fibrosis patients rescues CFTR function in differentiated epithelia S Vaidyanathan, AA Salahudeen, ZM Sellers, DT Bravo, SS Choi, ... Cell stem cell 26 (2), 161-171. e4, 2020 | 136 | 2020 |
| Global transcriptional response to CRISPR/Cas9-AAV6-based genome editing in CD34+ hematopoietic stem and progenitor cells MK Cromer, S Vaidyanathan, DE Ryan, B Curry, AB Lucas, J Camarena, ... Molecular Therapy 26 (10), 2431-2442, 2018 | 125 | 2018 |
| Priming human repopulating hematopoietic stem and progenitor cells for Cas9/sgRNA gene targeting CT Charlesworth, J Camarena, MK Cromer, S Vaidyanathan, RO Bak, ... Molecular Therapy Nucleic Acids 12, 89-104, 2018 | 107 | 2018 |
| Role of cell membrane–vector interactions in successful gene delivery S Vaidyanathan, BG Orr, MM Banaszak Holl Accounts of chemical research 49 (8), 1486-1493, 2016 | 88 | 2016 |
| Cationic polymer intercalation into the lipid membrane enables intact polyplex DNA escape from endosomes for gene delivery S Vaidyanathan, J Chen, BG Orr, MM Banaszak Holl Molecular pharmaceutics 13 (6), 1967-1978, 2016 | 66 | 2016 |
| Quantitative measurement of cationic polymer vector and polymer–pDNA polyplex intercalation into the cell plasma membrane S Vaidyanathan, KB Anderson, RL Merzel, B Jacobovitz, MP Kaushik, ... ACS nano 9 (6), 6097-6109, 2015 | 53 | 2015 |
| Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus S Vaidyanathan, R Baik, L Chen, DT Bravo, CJ Suarez, SM Abazari, ... Molecular Therapy 30 (1), 223-237, 2022 | 49 | 2022 |
| High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition S Selvaraj, WN Feist, S Viel, S Vaidyanathan, AM Dudek, M Gastou, ... Nature biotechnology 42 (5), 731-744, 2024 | 45 | 2024 |
| Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division RL Matz, B Erickson, S Vaidyanathan, JF Kukowska-Latallo, JR Baker Jr, ... Molecular pharmaceutics 10 (4), 1306-1317, 2013 | 39 | 2013 |
| Correction of recessive dystrophic epidermolysis bullosa by homology-directed repair-mediated genome editing J Bonafont, A Mencía, E Chacón-Solano, W Srifa, S Vaidyanathan, ... Molecular Therapy 29 (6), 2008-2018, 2021 | 37 | 2021 |
| PAMAM dendrimers as quantized building blocks for novel nanostructures MA Van Dongen, S Vaidyanathan, MMB Holl Soft Matter 9 (47), 11188-11196, 2013 | 37 | 2013 |
| Detergent induction of HEK 293A cell membrane permeability measured under quiescent and superfusion conditions using whole cell patch clamp S Vaidyanathan, BG Orr, MM Banaszak Holl The Journal of Physical Chemistry B 118 (8), 2112-2123, 2014 | 36 | 2014 |
| Fluorophore: dendrimer ratio impacts cellular uptake and intracellular fluorescence lifetime CA Dougherty, S Vaidyanathan, BG Orr, MM Banaszak Holl Bioconjugate chemistry 26 (2), 304-315, 2015 | 31 | 2015 |
| Polyplex-induced cytosolic nuclease activation leads to differential transgene expression R Rattan, S Vaidyanathan, GSH Wu, A Shakya, BG Orr, ... Molecular pharmaceutics 10 (8), 3013-3022, 2013 | 27 | 2013 |
| CFTR genotype analysis of Asians in international registries highlights disparities in the diagnosis and treatment of Asian patients with cystic fibrosis S Vaidyanathan, AM Trumbull, L Bar, M Rao, Y Yu, ZM Sellers Genetics in medicine 24 (10), 2180-2186, 2022 | 15 | 2022 |
| DNA immobilization on GaP (100) investigated by kelvin probe force microscopy DN Richards, DY Zemlyanov, RM Asrar, YY Chokshi, EM Cook, TJ Hinton, ... The Journal of Physical Chemistry C 114 (36), 15486-15490, 2010 | 14 | 2010 |
| Investigating adverse genomic and regulatory changes caused by replacement of the full-length CFTR cDNA using Cas9 and AAV S Vaidyanathan, JL Kerschner, A Paranjapye, V Sinha, B Lin, ... Molecular Therapy-Nucleic Acids 35 (1), 2024 | 7 | 2024 |
| Lung stem cells and therapy for cystic fibrosis S Vaidyanathan, M McCarra, TJ Desai ERS Monograph 2021 (91), 306-321, 2021 | 7 | 2021 |