| Characterization of CHO hydrogen bonds on the basis of the charge density U Koch, PLA Popelier The Journal of Physical Chemistry 99 (24), 9747-9754, 1995 | 3360 | 1995 |
| Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ... Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007 | 647 | 2007 |
| Product inhibition of the hepatitis C virus NS3 protease C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ... Biochemistry 37 (25), 8899-8905, 1998 | 315 | 1998 |
| Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ... Journal of Biological Chemistry 280 (33), 29765-29770, 2005 | 207 | 2005 |
| Discovery of MK-5172, a macrocyclic hepatitis C virus NS3/4a protease inhibitor S Harper, JA McCauley, MT Rudd, M Ferrara, M DiFilippo, B Crescenzi, ... ACS medicinal chemistry letters 3 (4), 332-336, 2012 | 206 | 2012 |
| A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ... Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002 | 202 | 2002 |
| Small-molecule inhibitors of human mitochondrial DNA transcription NA Bonekamp, B Peter, HS Hillen, A Felser, T Bergbrede, A Choidas, ... Nature 588 (7839), 712-716, 2020 | 183 | 2020 |
| Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase V Summa, A Petrocchi, P Pace, VG Matassa, R De Francesco, S Altamura, ... Journal of medicinal chemistry 47 (1), 14-17, 2004 | 180 | 2004 |
| Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides L Tomei, S Altamura, L Bartholomew, M Bisbocci, C Bailey, M Bosserman, ... Journal of virology 78 (2), 938-946, 2004 | 170 | 2004 |
| In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ... Journal of virology 77 (6), 3669-3679, 2003 | 160 | 2003 |
| 2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ... Journal of Medicinal Chemistry 49 (5), 1693-1705, 2006 | 156 | 2006 |
| Assessing different classification methods for virtual screening D Plewczynski, SAH Spieser, U Koch Journal of chemical information and modeling 46 (3), 1098-1106, 2006 | 151 | 2006 |
| BIGCHEM: challenges and opportunities for big data analysis in chemistry IV Tetko, O Engkvist, U Koch, JL Reymond, H Chen Molecular informatics 35 (11-12), 615-621, 2016 | 142 | 2016 |
| Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase U Koch, F Narjes Current topics in medicinal chemistry 7 (13), 1302-1329, 2007 | 141 | 2007 |
| α-Ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease F Narjes, M Brunetti, S Colarusso, B Gerlach, U Koch, G Biasiol, D Fattori, ... Biochemistry 39 (7), 1849-1861, 2000 | 92 | 2000 |
| From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety A Petrocchi, U Koch, VG Matassa, B Pacini, KA Stillmock, V Summa Bioorganic & medicinal chemistry letters 17 (2), 350-353, 2007 | 84 | 2007 |
| Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and … DO Cicero, G Barbato, U Koch, P Ingallinella, E Bianchi, MC Nardi, ... Journal of molecular biology 289 (2), 385-396, 1999 | 78 | 1999 |
| Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control Y Wang, A Kirschner, AK Fabian, R Gopalakrishnan, C Kress, ... Journal of medicinal chemistry 56 (10), 3922-3935, 2013 | 77 | 2013 |
| Conformational dependence of atomic multipole moments U Koch, PLA Popelier, AJ Stone Chemical physics letters 238 (4-6), 253-260, 1995 | 73 | 1995 |
| Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease S Colarusso, B Gerlach, U Koch, E Muraglia, I Conte, I Stansfield, ... Bioorganic & medicinal chemistry letters 12 (4), 705-708, 2002 | 71 | 2002 |
