Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development TJ Kamerzell, R Esfandiary, SB Joshi, CR Middaugh, DB Volkin Advanced drug delivery reviews 63 (13), 1118-1159, 2011 | 577 | 2011 |
The complex inter-relationships between protein flexibility and stability TJ Kamerzell, CR Middaugh Journal of pharmaceutical sciences 97 (9), 3494-3517, 2008 | 142 | 2008 |
Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies A Chaudhri, IE Zarraga, TJ Kamerzell, JP Brandt, TW Patapoff, SJ Shire, ... The Journal of Physical Chemistry B 116 (28), 8045-8057, 2012 | 138 | 2012 |
Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties TJ Kamerzell, S Kanai, J Liu, SJ Shire, YJ Wang The Journal of Physical Chemistry B 113 (17), 6109-6118, 2009 | 64 | 2009 |
Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability JD Ramsey, ML Gill, TJ Kamerzell, ES Price, SB Joshi, SM Bishop, ... Journal of pharmaceutical sciences 98 (7), 2432-2447, 2009 | 48 | 2009 |
Two-dimensional correlation spectroscopy reveals coupled immunoglobulin regions of differential flexibility that influence stability TJ Kamerzell, CR Middaugh Biochemistry 46 (34), 9762-9773, 2007 | 48 | 2007 |
Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability TJ Kamerzell, JD Ramsey, CR Middaugh The Journal of Physical Chemistry B 112 (10), 3240-3250, 2008 | 45 | 2008 |
The relative rate of immunoglobulin gamma 1 fragmentation TJ Kamerzell, M Li, S Arora, JA Ji, YJ Wang Journal of pharmaceutical sciences 100 (4), 1341-1349, 2011 | 36 | 2011 |
Characteristics of rhVEGF release from topical hydrogel formulations JA Ji, J Liu, SJ Shire, TJ Kamerzell, S Hong, K Billeci, Y Shen, YJ Wang Pharmaceutical research 27, 644-654, 2010 | 29 | 2010 |
Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification TJ Kamerzell, SB Joshi, D McClean, L Peplinskie, K Toney, D Papac, M Li, ... Protein science 16 (6), 1193-1203, 2007 | 28 | 2007 |
Conformational flexibility, hydration and state parameter fluctuations of fibroblast growth factor-10: effects of ligand binding TJ Kamerzell, JR Unruh, CK Johnson, CR Middaugh Biochemistry 45 (51), 15288-15300, 2006 | 27 | 2006 |
Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: formulation and biocompatibility considerations TJ Kamerzell, AL Pace, M Li, DM Danilenko, M McDowell, YR Gokarn, ... Journal of pharmaceutical sciences 102 (4), 1182-1193, 2013 | 25 | 2013 |
The interaction of heparin/polyanions with bovine, porcine, and human growth hormone SB Joshi, TJ Kamerzell, C McNown, CR Middaugh Journal of pharmaceutical sciences 97 (4), 1368-1385, 2008 | 25 | 2008 |
Prediction machines: applied machine learning for therapeutic protein design and development TJ Kamerzell, CR Middaugh Journal of Pharmaceutical Sciences 110 (2), 665-681, 2021 | 24 | 2021 |
Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization B Connolly, TW Patapoff, YJ Wang, JM Moore, TJ Kamerzell Analytical biochemistry 399 (1), 48-57, 2010 | 21 | 2010 |
Spectroscopy and photophysics of indoline and indoline-2-carboxylic acid MW Allen, JR Unruh, BD Slaughter, SJ Pyszczynski, TR Hellwig, ... The Journal of Physical Chemistry A 107 (30), 5660-5669, 2003 | 19 | 2003 |
Thermodynamic and structural characterization of an antibody gel O Esue, AX Xie, TJ Kamerzell, TW Patapoff MAbs 5 (2), 323-334, 2013 | 12 | 2013 |
Concentrated polypeptide formulations with reduced viscosity T Kamerzell, S Martin-Moe, YJ Wang US Patent App. 13/388,962, 2013 | 6 | 2013 |
The structural basis of histone modifying enzyme specificity and promiscuity: implications for metabolic regulation and drug design TJ Kamerzell, B Mikell, L Chen, H Elias, B Dawn, C MacRae, ... Advances in Protein Chemistry and Structural Biology 130, 189-243, 2022 | 1 | 2022 |
Coarse-grained modeling of antibody self-association A Chaudhri, T Kamerzell, GA Voth ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240, 2010 | 1 | 2010 |