| De novo proteins with life-sustaining functions are structurally dynamic GS Murphy, JB Greisman, MH Hecht Journal of Molecular Biology 428 (2), 399-411, 2016 | 34 | 2016 |
| A unifying Bayesian framework for merging X-ray diffraction data KM Dalton, JB Greisman, DR Hekstra Nature Communications 13 (1), 7764, 2022 | 31 | 2022 |
| reciprocalspaceship: a Python library for crystallographic data analysis JB Greisman, KM Dalton, DR Hekstra Applied Crystallography 54 (5), 1521-1529, 2021 | 26 | 2021 |
| Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors AM Taylor, BR Williams, F Giordanetto, EH Kelley, A Lescarbeau, ... Journal of Medicinal Chemistry 66 (19), 13384-13399, 2023 | 23 | 2023 |
| Discovery and validation of the binding poses of allosteric fragment hits to protein tyrosine phosphatase 1b: From molecular dynamics simulations to X-ray crystallography JB Greisman, L Willmore, CY Yeh, F Giordanetto, S Shahamadtar, ... Journal of Chemical Information and Modeling 63 (9), 2644-2650, 2023 | 21 | 2023 |
| SHP2 Phosphatase inhibitors and methods of use thereof BK Albrecht, F Giordanetto, JB Greisman, P Maragakis, AM Taylor, ... US Patent 11,529,347, 2022 | 12 | 2022 |
| Native SAD phasing at room temperature JB Greisman, KM Dalton, CJ Sheehan, MA Klureza, I Kurinov, DR Hekstra Biological Crystallography 78 (8), 986-996, 2022 | 12 | 2022 |
| Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism JB Greisman, KM Dalton, DE Brookner, MA Klureza, CJ Sheehan, IS Kim, ... Proceedings of the National Academy of Sciences 121 (9), e2313192121, 2024 | 11 | 2024 |
| Pyrazolo [3, 4-b] pyrazine derivatives as SHP2 phosphatase inhibitors AM Taylor, WP Walters, MA Murcko, F Giordanetto, E Therrien, S Bhat, ... US Patent 11,701,354, 2023 | 9 | 2023 |
| SHP2 phosphatase inhibitors and methods of use thereof F Giordanetto, JB Greisman, P Maragakis, AM Taylor, LV DiPietro, ... US Patent 11,629,145, 2023 | 9 | 2023 |
| A conserved local structural motif controls the kinetics of PTP1B catalysis CY Yeh, JA Izaguirre, JB Greisman, L Willmore, P Maragakis, DE Shaw Journal of Chemical Information and Modeling 63 (13), 4115-4124, 2023 | 7 | 2023 |
| Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors B Williams, A Taylor, O Orozco, C Owen, E Kelley, A Lescarbeau, ... Cancer Res 82 (12_Suppl), 3327, 2022 | 7 | 2022 |
| Shp2 phosphatase inhibitors and methods of use thereof WP Walters, A Lescarbeau, EH Kelley, KC Shortsleeves, AM Taylor, ... US Patent App. 16/971,435, 2020 | 7 | 2020 |
| Pyrazolo [3, 4-b] pyrazine SHP2 phosphatase inhibitors and methods of use thereof AM Taylor, F Giordanetto, JB Greisman, P Maragakis, H Schoenherr US Patent 12,138,263, 2024 | 6 | 2024 |
| Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme JB Greisman, KM Dalton, DE Brookner, MA Klureza, CJ Sheehan, IS Kim, ... bioRxiv, 2023 | 6 | 2023 |
| Substituted pyrazolo [3, 4-b] pyrazines as SHP2 phosphatase inhibitors AM Taylor, A Lescarbeau, EH Kelley, KC Shortsleeves, LV DiPietro, ... US Patent 11,591,336, 2023 | 6 | 2023 |
| Discovery and validation of the binding poses of allosteric fragment hits to PTP1B: From molecular dynamics simulations to X-ray crystallography JB Greisman, L Willmore, CY Yeh, F Giordanetto, S Shahamadtar, ... bioRxiv, 2022.11. 14.516467, 2022 | 2 | 2022 |
| Sensitive Detection of Structural Differences using a Statistical Framework for Comparative Crystallography DR Hekstra, HK Wang, MA Klureza, JB Greisman, KM Dalton bioRxiv, 2024 | 1 | 2024 |
| Careless: A Variational Bayesian Model for Merging X-ray Diffraction Data KM Dalton, JB Greisman, DR Hekstra bioRxiv, 2021.01. 05.425510, 2021 | 1 | 2021 |
| Laue-DIALS: Open-source software for polychromatic x-ray diffraction data RA Hewitt, KM Dalton, DA Mendez, HK Wang, MA Klureza, DE Brookner, ... Structural Dynamics 11 (5), 2024 | | 2024 |
Doeke Romke HekstraHarvard UniversityПідтверджена електронна адреса в g.harvard.edu