TREM2 function impedes tau seeding in neuritic plaques CEG Leyns, M Gratuze, S Narasimhan, N Jain, LJ Koscal, H Jiang, ... Nature neuroscience 22 (8), 1217-1222, 2019 | 269 | 2019 |
ApoE isoform–and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy D Seo, D O’Donnell, N Jain, JD Ulrich, J Herz, Y Li, M Lemieux, J Cheng, ... Science 379 (6628), eadd1236, 2023 | 160 | 2023 |
Activated microglia mitigate Aβ-associated tau seeding and spreading M Gratuze, Y Chen, S Parhizkar, N Jain, MR Strickland, JR Serrano, ... Journal of Experimental Medicine 218 (8), e20210542, 2021 | 151 | 2021 |
GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein ME Diaz-Ortiz, Y Seo, M Posavi, M Carceles Cordon, E Clark, N Jain, ... Science 377 (6608), eabk0637, 2022 | 102 | 2022 |
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading N Jain, CA Lewis, JD Ulrich, DM Holtzman Journal of Experimental Medicine 220 (1), 2023 | 92 | 2023 |
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints Z Yin, N Rosenzweig, KL Kleemann, X Zhang, W Brandão, MA Margeta, ... Nature immunology 24 (11), 1839-1853, 2023 | 85 | 2023 |
Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes JI Busch, TL Unger, N Jain, R Tyler Skrinak, RA Charan, AS Chen-Plotkin Human molecular genetics 25 (13), 2681-2697, 2016 | 73 | 2016 |
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 M Gratuze, JCM Schlachetzki, RDO Albanus, N Jain, B Novotny, L Brase, ... Neuron 111 (2), 202-219. e7, 2023 | 59 | 2023 |
Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype CA Cooper, N Jain, MD Gallagher, D Weintraub, SX Xie, Y Berlyand, ... Annals of clinical and translational neurology 4 (1), 15-25, 2017 | 41 | 2017 |
Genetic modifiers in neurodegeneration N Jain, AS Chen-Plotkin Current genetic medicine reports 6, 11-19, 2018 | 24 | 2018 |
Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions A Ray, P Katoch, N Jain, PP Mehta Journal of cell science 131 (5), jcs207340, 2018 | 15 | 2018 |
TREM2 and microglia exosomes: a potential highway for pathological tau N Jain, JD Ulrich Molecular neurodegeneration 17 (1), 73, 2022 | 11 | 2022 |
Insights from new in vivo models of TREM2 variants N Jain, DM Holtzman Molecular neurodegeneration 18 (1), 21, 2023 | 3 | 2023 |
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy W Brandao, N Jain, Z Yin, KL Kleemann, M Carpenter, X Bao, JR Serrano, ... Science Translational Medicine 17 (781), eadk3690, 2025 | | 2025 |
Degeneration N Jain | | 2024 |
APOE4 impairs Microglia‐Astrocyte Crosstalk in Alzheimer Disease K Kleemann, N Rosenzweig, Z Yin, X Zhang, WN Brandao, M Margeta, ... Alzheimer's & Dementia 19, e071852, 2023 | | 2023 |
APOE4 impairs microglia‐astrocyte response in Alzheimer’s disease by inducing TGFβ‐mediated checkpoints O Butovsky, Z Yin, N Rosenzweig, K Kleemann, X Zhang, WN Brandao, ... Alzheimer's & Dementia 19, e076510, 2023 | | 2023 |
Xenon gas (Xe) treatment to restore microglial functions in Alzheimer’s disease (AD) WN Brandao, Z Yin, K Kleemann, X Zhang, N Rosenzweig, N Jain, ... Alzheimer's & Dementia 19, e076467, 2023 | | 2023 |
Testing for Allele-specific Expression from Human Brain Samples ME Diaz-Ortiz, N Jain, MD Gallagher, M Posavi, TL Unger, ... Bio-protocol 13 (19), e4832, 2023 | | 2023 |
Suppressing ApoE ε4 allele protects against signs of Alzheimer’s disease Z Yin, N Rosenzweig, KL Kleemann, X Zhang, W Brandão, MA Margeta, ... | | 2023 |