| Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance F Martins, L Sofiya, GP Sykiotis, F Lamine, M Maillard, M Fraga, ... Nature reviews Clinical oncology 16 (9), 563-580, 2019 | 1925 | 2019 |
| Stress-activated cap'n'collar transcription factors in aging and human disease GP Sykiotis, D Bohmann Science signaling 3 (112), re3-re3, 2010 | 919 | 2010 |
| Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila GP Sykiotis, D Bohmann Developmental cell 14 (1), 76-85, 2008 | 732 | 2008 |
| Oligogenic basis of isolated gonadotropin-releasing hormone deficiency GP Sykiotis, L Plummer, VA Hughes, M Au, S Durrani, S Nayak-Young, ... Proceedings of the National Academy of Sciences 107 (34), 15140-15144, 2010 | 401 | 2010 |
| Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation PA Konstantinopoulos, A Kominea, G Vandoros, GP Sykiotis, ... European journal of cancer 39 (9), 1251-1258, 2003 | 395 | 2003 |
| Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism H Miraoui, AA Dwyer, GP Sykiotis, L Plummer, W Chung, B Feng, ... The American Journal of Human Genetics 92 (5), 725-743, 2013 | 318 | 2013 |
| A genetic basis for functional hypothalamic amenorrhea LM Caronia, C Martin, CK Welt, GP Sykiotis, R Quinton, A Thambundit, ... New England Journal of Medicine 364 (3), 215-225, 2011 | 301 | 2011 |
| The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation GP Sykiotis, IG Habeos, AV Samuelson, D Bohmann Current Opinion in Clinical Nutrition & Metabolic Care 14 (1), 41-48, 2011 | 262 | 2011 |
| Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism J Tornberg, GP Sykiotis, K Keefe, L Plummer, X Hoang, JE Hall, ... Proceedings of the National Academy of Sciences 108 (28), 11524-11529, 2011 | 221 | 2011 |
| Nrf2 represses FGF21 during long-term high-fat diet–induced obesity in mice DV Chartoumpekis, PG Ziros, AI Psyrogiannis, AG Papavassiliou, ... Diabetes 60 (10), 2465-2473, 2011 | 214 | 2011 |
| New therapeutic perspectives to manage refractory immune checkpoint-related toxicities F Martins, GP Sykiotis, M Maillard, M Fraga, C Ribi, T Kuntzer, O Michielin, ... The Lancet Oncology 20 (1), e54-e64, 2019 | 195 | 2019 |
| Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance GP Sykiotis, AG Papavassiliou Molecular Endocrinology 15 (11), 1864-1869, 2001 | 182 | 2001 |
| Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia T Raivio, M Avbelj, MJ McCabe, CJ Romero, AA Dwyer, J Tommiska, ... The Journal of Clinical Endocrinology & Metabolism 97 (4), E694-E699, 2012 | 172 | 2012 |
| Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes GP Sykiotis, XH Hoang, M Avbelj, FJ Hayes, A Thambundit, A Dwyer, ... The Journal of Clinical Endocrinology & Metabolism 95 (6), 3019-3027, 2010 | 157 | 2010 |
| Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism AA Dwyer, GP Sykiotis, FJ Hayes, PA Boepple, H Lee, KR Loughlin, ... The Journal of Clinical Endocrinology & Metabolism 98 (11), E1790-E1795, 2013 | 153 | 2013 |
| Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease MC Barone, GP Sykiotis, D Bohmann Disease models & mechanisms 4 (5), 701-707, 2011 | 146 | 2011 |
| Activation of the JNK–AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas DJ Papachristou, A Batistatou, GP Sykiotis, I Varakis, AG Papavassiliou Bone 32 (4), 364-371, 2003 | 145 | 2003 |
| Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures D Cassatella, SR Howard, JS Acierno, C Xu, GE Papadakis, FA Santoni, ... European journal of endocrinology 178 (4), 377-388, 2018 | 121 | 2018 |
| Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging EN Tsakiri, GP Sykiotis, IS Papassideri, E Terpos, MA Dimopoulos, ... Aging cell 12 (5), 802-813, 2013 | 115 | 2013 |
| Declining signal dependence of N rf2‐M af S‐regulated gene expression correlates with aging phenotypes MM Rahman, GP Sykiotis, M Nishimura, R Bodmer, D Bohmann Aging cell 12 (4), 554-562, 2013 | 114 | 2013 |
