| Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis MR Vargas, DA Johnson, DW Sirkis, A Messing, JA Johnson Journal of Neuroscience 28 (50), 13574-13581, 2008 | 550 | 2008 |
| Protein Sorting at the trans-Golgi Network Y Guo, DW Sirkis, R Schekman Annual review of cell and developmental biology 30 (1), 169-206, 2014 | 285 | 2014 |
| Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease DW Sirkis, LW Bonham, TP Johnson, R La Joie, JS Yokoyama Molecular psychiatry 27 (6), 2674-2688, 2022 | 101 | 2022 |
| Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway CS Asensio, DW Sirkis, JW Maas, K Egami, TL To, FM Brodsky, X Shu, ... Developmental cell 27 (4), 425-437, 2013 | 84 | 2013 |
| The transcriptional landscape of microglial genes in aging and neurodegenerative disease LW Bonham, DW Sirkis, JS Yokoyama Frontiers in immunology 10, 1170, 2019 | 77 | 2019 |
| RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway CS Asensio, DW Sirkis, RH Edwards Journal of Cell Biology 191 (6), 1173-1187, 2010 | 68 | 2010 |
| Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression DW Sirkis, LW Bonham, RE Aparicio, EG Geier, EM Ramos, Q Wang, ... Acta Neuropathologica Communications 4, 1-11, 2016 | 65 | 2016 |
| Recent advances in the genetics of frontotemporal dementia DW Sirkis, EG Geier, LW Bonham, CM Karch, JS Yokoyama Current genetic medicine reports 7, 41-52, 2019 | 63 | 2019 |
| C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity JS Yokoyama, DW Sirkis, BL Miller American journal of neurodegenerative disease 3 (1), 1, 2014 | 37 | 2014 |
| Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3 DW Sirkis, RH Edwards, CS Asensio PLoS genetics 9 (9), e1003812, 2013 | 37 | 2013 |
| Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia EG Geier, M Bourdenx, NJ Storm, JN Cochran, DW Sirkis, JH Hwang, ... Acta neuropathologica 137, 71-88, 2019 | 35 | 2019 |
| Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER–Golgi intermediate compartment DW Sirkis, RE Aparicio, R Schekman Molecular biology of the cell 28 (20), 2723-2733, 2017 | 34 | 2017 |
| Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma N Li, DJ Maly, YH Chanthery, DW Sirkis, JL Nakamura, MS Berger, ... Molecular cancer therapeutics 14 (2), 419-428, 2015 | 27 | 2015 |
| Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers S Wu, NCH Villegas, DW Sirkis, I Thomas-Wright, R Wade-Martins, ... Elife 12, e85837, 2023 | 22 | 2023 |
| The role of microglia in inherited white-matter disorders and connections to frontotemporal dementia DW Sirkis, LW Bonham, JS Yokoyama The application of clinical genetics 14, 195, 2021 | 19 | 2021 |
| Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer’s disease LW Bonham, DW Sirkis, J Fan, RE Aparicio, M Tse, EM Ramos, Q Wang, ... Neurocase 23 (1), 65-69, 2017 | 12 | 2017 |
| Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy DW Sirkis, C Warly Solsberg, TP Johnson, LW Bonham, VE Sturm, ... Genome Medicine 15 (1), 53, 2023 | 10 | 2023 |
| Radiogenomics of C9orf72 expansion carriers reveals global transposable element derepression and enables prediction of thalamic atrophy and clinical impairment LW Bonham, EG Geier, DW Sirkis, JK Leong, EM Ramos, Q Wang, ... Journal of Neuroscience 43 (2), 333-345, 2023 | 10 | 2023 |
| Immunological signatures in frontotemporal lobar degeneration DW Sirkis, LW Bonham, CM Karch, JS Yokoyama Current opinion in neurology 32 (2), 272-278, 2019 | 9 | 2019 |
| Frontotemporal dementia presentation in patients with heterozygous p. H157Y variant of TREM2 N Ogonowski, H Santamaria-Garcia, S Baez, A Lopez, A Laserna, ... Journal of Medical Genetics 60 (9), 894-904, 2023 | 6 | 2023 |