| Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation E Kassianidou, JH Hughes, S Kumar Molecular biology of the cell 28 (26), 3832-3843, 2017 | 89 | 2017 |
| A hybrid machine learning/pharmacokinetic approach outperforms maximum a posteriori Bayesian estimation by selectively flattening model priors JH Hughes, RJ Keizer CPT: pharmacometrics & systems pharmacology 10 (10), 1150-1160, 2021 | 50 | 2021 |
| Continuous learning in model‐informed precision dosing: a case study in pediatric dosing of vancomycin JH Hughes, DMH Tong, SS Lucas, JD Faldasz, S Goswami, RJ Keizer Clinical Pharmacology & Therapeutics 109 (1), 233-242, 2021 | 44 | 2021 |
| Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues JH Hughes, JM Ewy, J Chen, SY Wong, KM Tharp, A Stahl, S Kumar Matrix Biology 85, 112-127, 2020 | 16 | 2020 |
| Synthetic mechanobiology: engineering cellular force generation and signaling JH Hughes, S Kumar Current opinion in biotechnology 40, 82-89, 2016 | 16 | 2016 |
| Time‐lapse microscopy of macrophages during embryonic vascular development S Al‐Roubaie, JH Hughes, MB Filla, R Lansford, S Lehoux, EAV Jones Developmental Dynamics 241 (9), 1423-1431, 2012 | 16 | 2012 |
| Clinical decision support for chemotherapy‐induced neutropenia using a hybrid pharmacodynamic/machine learning model JH Hughes, DMH Tong, V Burns, B Daly, P Razavi, JJ Boelens, ... CPT: Pharmacometrics & Systems Pharmacology 12 (11), 1764-1776, 2023 | 13 | 2023 |
| Evaluation of neonatal and paediatric vancomycin pharmacokinetic models and the impact of maturation and serum creatinine covariates in a large multicentre data set JH Hughes, DMH Tong, JD Faldasz, A Frymoyer, RJ Keizer Clinical Pharmacokinetics 62 (1), 67-76, 2023 | 11 | 2023 |
| Clinical decision support for precision dosing: opportunities for enhanced equity and inclusion in health care JH Hughes, KH Woo, RJ Keizer, S Goswami Clinical Pharmacology & Therapeutics 113 (3), 565-574, 2023 | 9 | 2023 |
| Maximum a posteriori Bayesian methods out-perform non-compartmental analysis for busulfan precision dosing JH Hughes, J Long-Boyle, RJ Keizer Journal of Pharmacokinetics and Pharmacodynamics 51 (3), 279-288, 2024 | 6 | 2024 |
| Use of age-adjusted serum creatinine in a vancomycin pharmacokinetic model decreases predictive performance in elderly patients DMH Tong, JH Hughes, RJ Keizer Therapeutic Drug Monitoring 43 (1), 139-140, 2021 | 5 | 2021 |
| Evaluating and improving neonatal gentamicin pharmacokinetic models using aggregated routine clinical care data DMH Tong, JH Hughes, RJ Keizer Pharmaceutics 14 (10), 2089, 2022 | 4 | 2022 |
| PhD jobs: Support beyond academia. JH Hughes, KE Scheibel, AW Bremer Nature 551 (7680), 440-441, 2017 | 2 | 2017 |
| Impacts of age and BMI on vancomycin model choice in a Bayesian software: Lessons from a very large multi‐site retrospective study MSA Hughes, T Lee, JD Faldasz, JH Hughes Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 44 (10 …, 2024 | 1 | 2024 |
| Developing Parametric and Nonparametric Models for Model-Informed Precision Dosing: A Quality Improvement Effort in Vancomycin for Patients With Obesity MSA Hughes, JH Hughes, J Endicott, M Langton, JW Ahern, RJ Keizer Therapeutic Drug Monitoring 46 (5), 575-583, 2024 | 1 | 2024 |
| 211. Defining Optimal Sampling Times for Cefepime Therapeutic Drug Monitoring in Clinical Practice NJ Rhodes, B Smith, RK Shields, S Pan, E Weslander, S Galvin, ... Open Forum Infectious Diseases 12 (Supplement_1), ofae631. 069, 2025 | | 2025 |
| P-1253. Validating and Comparing the Predictiveness of Cefepime Pharmacokinetic Models Used in Bayesian Dosing MS Hughes, NJ Rhodes, B Smith, RK Shields, S Pan, E Weslander, ... Open Forum Infectious Diseases 12 (Supplement_1), ofae631. 1435, 2025 | | 2025 |
| P-1254. Improved Vancomycin Target Attainment Following a Quasi-Experimental Change in Pharmacokinetic Model for Bayesian Precision Dosing MS Hughes, DMH Tong, J Hughes Open Forum Infectious Diseases 12 (Supplement_1), ofae631. 1436, 2025 | | 2025 |
| P-1259. Transferring knowledge from gentamicin pharmacokinetics in neonates to other aminoglycosides T Lee, J Hughes, NM Hall, ML Brown, WS Edwards, J Faldasz Open Forum Infectious Diseases 12 (Supplement_1), ofae631. 1441, 2025 | | 2025 |
| Comparing two-sample log-linear exposure estimation with Bayesian model-informed precision dosing of tobramycin in adult patients with cystic fibrosis DMH Tong, MSA Hughes, J Hu, JC Pearson, DW Kubiak, BW Dionne, ... Antimicrobial Agents and Chemotherapy, e01040-24, 2025 | | 2025 |
Ron KeizerChief Scientific Officer, InsightRXПідтверджена електронна адреса в insight-rx.com
