Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation JP Brady, PJ Farber, A Sekhar, YH Lin, R Huang, A Bah, TJ Nott, ... Proceedings of the National Academy of Sciences 114 (39), E8194-E8203, 2017 | 481 | 2017 |
NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers A Sekhar, LE Kay Proceedings of the National Academy of Sciences 110 (32), 12867-12874, 2013 | 261 | 2013 |
An NMR view of protein dynamics in health and disease A Sekhar, LE Kay Annual review of biophysics 48 (1), 297-319, 2019 | 163 | 2019 |
Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer P Vallurupalli, A Sekhar, T Yuwen, LE Kay Journal of biomolecular NMR 67, 243-271, 2017 | 154 | 2017 |
Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways A Sekhar, JAO Rumfeldt, HR Broom, CM Doyle, G Bouvignies, ... elife 4, e07296, 2015 | 120 | 2015 |
Mapping the conformation of a client protein through the Hsp70 functional cycle A Sekhar, R Rosenzweig, G Bouvignies, LE Kay Proceedings of the National Academy of Sciences 112 (33), 10395-10400, 2015 | 104 | 2015 |
Hsp70 biases the folding pathways of client proteins A Sekhar, R Rosenzweig, G Bouvignies, LE Kay Proceedings of the National Academy of Sciences 113 (20), E2794-E2801, 2016 | 101 | 2016 |
Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles R Rosenzweig, A Sekhar, J Nagesh, LE Kay Elife 6, e28030, 2017 | 85 | 2017 |
Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions A Sekhar, A Velyvis, G Zoltsman, R Rosenzweig, G Bouvignies, LE Kay elife 7, e32764, 2018 | 80 | 2018 |
Effects of maturation on the conformational free-energy landscape of SOD1 RM Culik, A Sekhar, J Nagesh, H Deol, JAO Rumfeldt, EM Meiering, ... Proceedings of the National Academy of Sciences 115 (11), E2546-E2555, 2018 | 70 | 2018 |
Understanding the mechanism of proteasome 20S core particle gating MP Latham, A Sekhar, LE Kay Proceedings of the National Academy of Sciences 111 (15), 5532-5537, 2014 | 69 | 2014 |
Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy A Sekhar, JAO Rumfeldt, HR Broom, CM Doyle, RE Sobering, ... Proceedings of the National Academy of Sciences 113 (45), E6939-E6945, 2016 | 68 | 2016 |
Characterizing post-translational modifications and their effects on protein conformation using NMR spectroscopy A Kumar, V Narayanan, A Sekhar Biochemistry 59 (1), 57-73, 2019 | 61 | 2019 |
Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone JH Lee, D Zhang, C Hughes, Y Okuno, A Sekhar, S Cavagnero Proceedings of the National Academy of Sciences 112 (31), E4206-E4215, 2015 | 57 | 2015 |
1H-Detected 13C Photo-CIDNP as a Sensitivity Enhancement Tool in Solution NMR JH Lee, A Sekhar, S Cavagnero Journal of the American Chemical Society 133 (21), 8062-8065, 2011 | 56 | 2011 |
A universal pattern in the percolation and dissipation of protein structural perturbations N Rajasekaran, A Sekhar, AN Naganathan The journal of physical chemistry letters 8 (19), 4779-4784, 2017 | 44 | 2017 |
Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1H‐CEST T Yuwen, A Sekhar, LE Kay Angewandte Chemie International Edition 56 (22), 6122-6125, 2017 | 41 | 2017 |
Defining a length scale for millisecond-timescale protein conformational exchange A Sekhar, P Vallurupalli, LE Kay Proceedings of the National Academy of Sciences 110 (28), 11391-11396, 2013 | 41 | 2013 |
Concurrent increases and decreases in local stability and conformational heterogeneity in Cu, Zn superoxide dismutase variants revealed by temperature-dependence of amide … CM Doyle, JA Rumfeldt, HR Broom, A Sekhar, LE Kay, EM Meiering Biochemistry 55 (9), 1346-1361, 2016 | 38 | 2016 |
Self-assembly of human Profilin-1 detected by Carr–Purcell–Meiboom–Gill nuclear magnetic resonance (CPMG NMR) spectroscopy E Rennella, A Sekhar, LE Kay Biochemistry 56 (5), 692-703, 2017 | 35 | 2017 |