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David R Edgell
David R Edgell
Professor of Biochemistry, University of Western Ontario, London ON
Підтверджена електронна адреса в uwo.ca
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Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis
AD Fernandes, JN Reid, JM Macklaim, TA McMurrough, DR Edgell, ...
Microbiome 2, 1-13, 2014
10962014
Archaea and the origin(s) of DNA replication proteins
DR Edgell, WF Doolittle
Cell 89 (7), 995-998, 1997
3291997
Barriers to intron promiscuity in bacteria
DR Edgell, M Belfort, DA Shub
Journal of Bacteriology 182 (19), 5281-5289, 2000
1752000
An Expanded Plasmid-Based Genetic Toolbox Enables Cas9 Genome Editing and Stable Maintenance of Synthetic Pathways in Phaeodactylum tricornutum
SS Slattery, A Diamond, H Wang, JA Therrien, JT Lant, T Jazey, K Lee, ...
ACS synthetic biology 7 (2), 328-338, 2018
1542018
Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing
TA Hamilton, GM Pellegrino, JA Therrien, DT Ham, PC Bartlett, BJ Karas, ...
Nature communications 10 (1), 4544, 2019
1162019
Tapping natural reservoirs of homing endonucleases for targeted gene modification
R Takeuchi, AR Lambert, ANS Mak, K Jacoby, RJ Dickson, GB Gloor, ...
Proceedings of the National Academy of Sciences 108 (32), 13077-13082, 2011
1162011
Bacterial group I introns: mobile RNA catalysts
G Hausner, M Hafez, DR Edgell
Mobile DNA 5, 1-12, 2014
1102014
Mobile DNA elements in T4 and related phages
DR Edgell, EA Gibb, M Belfort
Virology journal 7, 1-15, 2010
962010
FhuD1, a ferric hydroxamate-binding lipoprotein in Staphylococcus aureus: a case of gene duplication and lateral transfer
MT Sebulsky, CD Speziali, BH Shilton, DR Edgell, DE Heinrichs
Journal of Biological Chemistry 279 (51), 53152-53159, 2004
922004
Learning to live together: mutualism between self-splicing introns and their hosts
DR Edgell, VR Chalamcharla, M Belfort
BMC biology 9, 1-9, 2011
912011
Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide
JC Kaiser, AN King, JC Grigg, JR Sheldon, DR Edgell, MEP Murphy, ...
PLoS genetics 14 (1), e1007159, 2018
902018
Genes within genes: multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa
J Sethuraman, A Majer, NC Friedrich, DR Edgell, G Hausner
Molecular biology and evolution 26 (10), 2299-2315, 2009
842009
Gene duplications in evolution of archaeal family B DNA polymerases
DR Edgell, HP Klenk, WF Doolittle
Journal of bacteriology 179 (8), 2632-2640, 1997
831997
mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
CV Pereira, SR Bacman, T Arguello, U Zekonyte, SL Williams, DR Edgell, ...
EMBO molecular medicine 10 (9), e8084, 2018
812018
Monomeric site-specific nucleases for genome editing
BP Kleinstiver, JM Wolfs, T Kolaczyk, AK Roberts, SX Hu, DR Edgell
Proceedings of the National Academy of Sciences 109 (21), 8061-8066, 2012
722012
Selfish DNA: homing endonucleases find a home
DR Edgell
Current Biology 19 (3), R115-R117, 2009
692009
Related homing endonucleases I-BmoI and I-TevI use different strategies to cleave homologous recognition sites
DR Edgell, DA Shub
Proceedings of the National Academy of Sciences 98 (14), 7898-7903, 2001
602001
High incidence of significant urinary ascorbic acid concentrations in a west coast population—implications for routine urinalysis
ML Brigden, D Edgell, M McPherson, A Leadbeater, G Hoag
Clinical Chemistry 38 (3), 426-431, 1992
581992
Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease
JM Wolfs, TA Hamilton, JT Lant, M Laforet, J Zhang, LM Salemi, GB Gloor, ...
Proceedings of the National Academy of Sciences 113 (52), 14988-14993, 2016
532016
Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor
DR Edgell, V Derbyshire, PV Roey, S LaBonne, MJ Stanger, Z Li, ...
Nature structural & molecular biology 11 (10), 936-944, 2004
522004
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