MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters BR Terlouw, K Blin, JC Navarro-Munoz, NE Avalon, MG Chevrette, ... Nucleic acids research 51 (D1), D603-D610, 2023 | 285 | 2023 |
Targeting bacterial genomes for natural product discovery E Kalkreuter, G Pan, AJ Cepeda, B Shen Trends in Pharmacological Sciences 41 (1), 13-26, 2020 | 110 | 2020 |
Engineering the substrate specificity of a modular polyketide synthase for installation of consecutive non-natural extender units E Kalkreuter, JM CroweTipton, AN Lowell, DH Sherman, GJ Williams Journal of the American Chemical Society 141 (5), 1961-1969, 2019 | 53 | 2019 |
Engineering enzymatic assembly lines for the production of new antimicrobials E Kalkreuter, GJ Williams Current Opinion in Microbiology 45, 140-148, 2018 | 37 | 2018 |
Cryptic and stereospecific hydroxylation, oxidation, and reduction in platensimycin and platencin biosynthesis LB Dong, X Zhang, JD Rudolf, MR Deng, E Kalkreuter, AJ Cepeda, ... Journal of the American Chemical Society 141 (9), 4043-4050, 2019 | 34 | 2019 |
Characterization and crystal structure of a nonheme diiron monooxygenase involved in platensimycin and platencin biosynthesis LB Dong, YC Liu, AJ Cepeda, E Kalkreuter, MR Deng, JD Rudolf, ... Journal of the American Chemical Society 141 (31), 12406-12412, 2019 | 31 | 2019 |
Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase E Kalkreuter, KS Bingham, AM Keeler, AN Lowell, JJ Schmidt, ... Nature Communications 12, 2193, 2021 | 27 | 2021 |
Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli E Kalkreuter, AM Keeler, AA Malico, KS Bingham, AK Gayen, GJ Williams ACS synthetic biology 8 (6), 1391-1400, 2019 | 24 | 2019 |
Cryptic sulfur incorporation in thioangucycline biosynthesis M Cao, C Zheng, D Yang, E Kalkreuter, A Adhikari, YC Liu, ME Rateb, ... Angewandte Chemie 133 (13), 7216-7223, 2021 | 19 | 2021 |
Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase S Meng, AD Steele, W Yan, G Pan, E Kalkreuter, YC Liu, Z Xu, B Shen Nature Communications 12 (1), 5672, 2021 | 13 | 2021 |
A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products M Bhardwaj, Z Cui, E Daniel Hankore, FH Moonschi, ... Proceedings of the National Academy of Sciences 120 (9), e2220468120, 2023 | 12 | 2023 |
Intramolecular C–C bond formation links anthraquinone and enediyne scaffolds in tiancimycin biosynthesis C Gui, E Kalkreuter, YC Liu, A Adhikari, CN Teijaro, D Yang, C Chang, ... Journal of the American Chemical Society 144 (44), 20452-20462, 2022 | 12 | 2022 |
Stem cell patents—reexamination/litigation—the last 5 years Y Shyntum, E Kalkreuter Tissue Engineering Part B: Reviews 15 (1), 87-90, 2009 | 9 | 2009 |
PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases CJ Zheng, E Kalkreuter, BY Fan, YC Liu, LB Dong, B Shen ACS chemical biology 16 (1), 96-105, 2020 | 8 | 2020 |
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration MM Zdouc, K Blin, NLL Louwen, J Navarro, C Loureiro, CD Bader, ... Nucleic acids research 53 (D1), D678-D690, 2025 | 7 | 2025 |
Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis C Gui, E Kalkreuter, YC Liu, G Li, AD Steele, D Yang, C Chang, B Shen Nature chemical biology 20 (2), 243-250, 2024 | 5 | 2024 |
Precursor-directed biosynthesis and semi-synthesis of natural products E Kalkreuter, SM Carpenter, GJ Williams | 5 | 2018 |
The Natural Products Discovery Center: Release of the first 8490 sequenced strains for exploring Actinobacteria biosynthetic diversity E Kalkreuter, SA Kautsar, D Yang, CD Bader, CN Teijaro, LL Fluegel, ... bioRxiv, 2023.12. 14.571759, 2024 | 3 | 2024 |
Hybrid Peptide–Polyketide Natural Product Biosynthesis AD Steele, E Kalkreuter, G Pan, S Meng, B Shen Elsevier, 2020 | 3 | 2020 |
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate C Gui, E Kalkreuter, L Lauterbach, D Yang, B Shen Nature Chemical Biology 20 (9), 1210-1219, 2024 | 2 | 2024 |