| Production of α1, 3-galactosyltransferase-deficient pigs CJ Phelps, C Koike, TD Vaught, J Boone, KD Wells, SH Chen, S Ball, ... Science 299 (5605), 411-414, 2003 | 1429 | 2003 |
| Single-cell analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns M Enge, HE Arda, M Mignardi, J Beausang, R Bottino, SK Kim, SR Quake Cell 171 (2), 321-330. e14, 2017 | 545 | 2017 |
| Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion T Delong, TA Wiles, RL Baker, B Bradley, G Barbour, R Reisdorph, ... Science 351 (6274), 711-714, 2016 | 523 | 2016 |
| Clinical xenotransplantation: the next medical revolution? B Ekser, M Ezzelarab, H Hara, DJ van der Windt, M Wijkstrom, R Bottino, ... The lancet 379 (9816), 672-683, 2012 | 443 | 2012 |
| Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus H Chen, X Gu, I Su, R Bottino, JL Contreras, A Tarakhovsky, SK Kim Genes & development 23 (8), 975-985, 2009 | 434 | 2009 |
| Improved human islet isolation using a new enzyme blend, liberase E Linetsky, R Bottino, R Lehmann, R Alejandro, L Inverardi, C Ricordi Diabetes 46 (7), 1120-1123, 1997 | 389 | 1997 |
| Response of human islets to isolation stress and the effect of antioxidant treatment R Bottino, AN Balamurugan, H Tse, C Thirunavukkarasu, X Ge, ... Diabetes 53 (10), 2559-2568, 2004 | 366 | 2004 |
| PDGF signalling controls age-dependent proliferation in pancreatic β-cells H Chen, X Gu, Y Liu, J Wang, SE Wirt, R Bottino, H Schorle, J Sage, ... Nature 478 (7369), 349-355, 2011 | 318 | 2011 |
| Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes JAB Babon, ME DeNicola, DM Blodgett, I Crèvecoeur, TS Buttrick, ... Nature medicine 22 (12), 1482-1487, 2016 | 314 | 2016 |
| Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets DJ Van Der Windt, R Bottino, A Casu, N Campanile, C Smetanka, J He, ... American Journal of Transplantation 9 (12), 2716-2726, 2009 | 312 | 2009 |
| Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. R Bottino, LA Fernandez, C Ricordi, R Lehmann, MF Tsan, R Oliver, ... Diabetes 47 (3), 316-323, 1998 | 302 | 1998 |
| Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function HE Arda, L Li, J Tsai, EA Torre, Y Rosli, H Peiris, RC Spitale, C Dai, X Gu, ... Cell metabolism 23 (5), 909-920, 2016 | 250 | 2016 |
| Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound R Bottino, AN Balamurugan, S Bertera, M Pietropaolo, M Trucco, ... Diabetes 51 (8), 2561-2567, 2002 | 227 | 2002 |
| A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene M King, T Pearson, LD Shultz, J Leif, R Bottino, M Trucco, MA Atkinson, ... Clinical immunology 126 (3), 303-314, 2008 | 215 | 2008 |
| α cell function and gene expression are compromised in type 1 diabetes M Brissova, R Haliyur, D Saunders, S Shrestha, C Dai, DM Blodgett, ... Cell reports 22 (10), 2667-2676, 2018 | 211 | 2018 |
| Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies DJ Van Der Windt, R Bottino, A Casu, N Campanile, DKC Cooper Xenotransplantation 14 (4), 288-297, 2007 | 210 | 2007 |
| Sirolimus is associated with reduced islet engraftment and impaired β-cell function N Zhang, D Su, S Qu, T Tse, R Bottino, AN Balamurugan, J Xu, ... Diabetes 55 (9), 2429-2436, 2006 | 209 | 2006 |
| Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells J Lee, T Sugiyama, Y Liu, J Wang, X Gu, J Lei, JF Markmann, S Miyazaki, ... elife 2, e00940, 2013 | 193 | 2013 |
| SARS-CoV-2 cell entry factors ACE2 and TMPRSS2 are expressed in the microvasculature and ducts of human pancreas but are not enriched in β cells KC Coate, J Cha, S Shrestha, W Wang, LM Gonçalves, J Almaça, ... Cell metabolism 32 (6), 1028-1040. e4, 2020 | 188 | 2020 |
| Cystic fibrosis–related diabetes is caused by islet loss and inflammation NJ Hart, R Aramandla, G Poffenberger, C Fayolle, AH Thames, A Bautista, ... JCI insight 3 (8), e98240, 2018 | 187 | 2018 |
