| Toward ‘omic scale metabolite profiling: a dual separation–mass spectrometry approach for coverage of lipid and central carbon metabolism J Ivanisevic, ZJ Zhu, L Plate, R Tautenhahn, S Chen, PJ O’Brien, ... Analytical chemistry 85 (14), 6876-6884, 2013 | 327 | 2013 |
| “Inverse drug discovery” strategy to identify proteins that are targeted by latent electrophiles as exemplified by aryl fluorosulfates DE Mortenson, GJ Brighty, L Plate, G Bare, W Chen, S Li, H Wang, ... Journal of the American Chemical Society 140 (1), 200-210, 2018 | 269 | 2018 |
| Arylfluorosulfates inactivate intracellular lipid binding protein (s) through chemoselective SuFEx reaction with a binding site Tyr residue W Chen, J Dong, L Plate, DE Mortenson, GJ Brighty, S Li, Y Liu, ... Journal of the American Chemical Society 138 (23), 7353-7364, 2016 | 257 | 2016 |
| Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ... elife 5, e15550, 2016 | 221 | 2016 |
| Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network L Plate, MA Marletta Molecular cell 46 (4), 449-460, 2012 | 217 | 2012 |
| Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis EA Blackwood, K Azizi, DJ Thuerauf, RJ Paxman, L Plate, JW Kelly, ... Nature communications 10 (1), 187, 2019 | 177 | 2019 |
| Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior L Plate, MA Marletta Trends in biochemical sciences 38 (11), 566-575, 2013 | 134 | 2013 |
| Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus nonstructural proteins identifies unique and shared host-cell dependencies JP Davies, KM Almasy, EF McDonald, L Plate ACS infectious diseases 6 (12), 3174-3189, 2020 | 131 | 2020 |
| Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming JMD Grandjean, A Madhavan, L Cech, BO Seguinot, RJ Paxman, E Smith, ... Nature chemical biology 16 (10), 1052-1061, 2020 | 127 | 2020 |
| Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins R Paxman, L Plate, EA Blackwood, C Glembotski, ET Powers, ... elife 7, e37168, 2018 | 108 | 2018 |
| Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain WRL Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW Proc Natl Acad Sci U S A 111 (36), 13046-51, 2014 | 101* | 2014 |
| Regulating secretory proteostasis through the unfolded protein response: from function to therapy L Plate, RL Wiseman Trends in cell biology 27 (10), 722-737, 2017 | 93 | 2017 |
| Regulated in development and DNA damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental … O Alvarez‐Garcia, T Matsuzaki, M Olmer, L Plate, JW Kelly, MK Lotz Arthritis & rheumatology 69 (7), 1418-1428, 2017 | 88 | 2017 |
| Benchmarking AlphaFold2 on peptide structure prediction EF McDonald, T Jones, L Plate, J Meiler, A Gulsevin Structure 31 (1), 111-119. e2, 2023 | 81 | 2023 |
| The unfolded protein response regulator ATF6 promotes mesodermal differentiation H Kroeger, N Grimsey, R Paxman, WC Chiang, L Plate, Y Jones, ... Science signaling 11 (517), eaan5785, 2018 | 74 | 2018 |
| Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients JD Schonhoft, C Monteiro, L Plate, YS Eisele, JM Kelly, D Boland, ... Science translational medicine 9 (407), eaam7621, 2017 | 67 | 2017 |
| Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether SE Torres, CM Gallagher, L Plate, M Gupta, CR Liem, X Guo, R Tian, ... Elife 8, e46595, 2019 | 62 | 2019 |
| Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates P García-Huerta, P Troncoso-Escudero, D Wu, A Thiruvalluvan, ... Acta neuropathologica 140, 737-764, 2020 | 58 | 2020 |
| The endoplasmic reticulum HSP 40 co‐chaperone ER dj3/DNAJB 11 assembles and functions as a tetramer KC Chen, S Qu, S Chowdhury, IC Noxon, JD Schonhoft, L Plate, ... The EMBO journal 36 (15), 2296-2309, 2017 | 54 | 2017 |
| Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing JMD Grandjean, L Plate, RI Morimoto, MJ Bollong, ET Powers, ... ACS chemical biology 14 (4), 784-795, 2019 | 52 | 2019 |