John R. Engen

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Thomas E. WalesResearch Professor, Northeastern UniversityEmail được xác minh tại neu.edu
Roxana IacobResearch Associate Professor, Northeastern UniversityEmail được xác minh tại neu.edu
Thomas E. SmithgallUniversity of PittsburghEmail được xác minh tại pitt.edu
Loren D. WalenskyProfessor of Pediatrics, Dana-Farber Cancer Institute and Harvard Medical SchoolEmail được xác minh tại dfci.harvard.edu
Nathanael S. GrayProfessor of Chemical and Systems BiologyEmail được xác minh tại stanford.edu
Jamie A. MorocoPrincipal Scientist, Photys TherapeuticsEmail được xác minh tại photys.com
Amy AndreottiEmail được xác minh tại iastate.edu
Timothy SpringerHarvard Medical School, Childrens Hospital BostonEmail được xác minh tại crystal.harvard.edu
Jarrod A. MartoDana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical SchoolEmail được xác minh tại dfci.harvard.edu
Pasi JanneDana Farber Cancer InstituteEmail được xác minh tại dfci.harvard.edu
Ken WestoverAssociate Professor of Biochemistry and Radiation Oncology, UT SouthwesternEmail được xác minh tại utsouthwestern.edu
Miklos GuttmanUniversity of Washington, SeattleEmail được xác minh tại uw.edu
Daniele PeterlePeptoneEmail được xác minh tại peptone.io
Ulrich HartlDirector, Max Planck Institute of BiochemistryEmail được xác minh tại biochem.mpg.de
olga gurskyProfessor of Physiology and Biophysics, Boston University School of MedicineEmail được xác minh tại bu.edu
Stephen BlacklowHarvard Medical SchoolEmail được xác minh tại hms.harvard.edu
M. Hayer-Hartl; M.K. Hayer; M.K. Haye...Max Planck Institute of BiochemistryEmail được xác minh tại biochem.mpg.de
Giulio Superti-FurgaScientific Director, CeMM Research Center for Molecular Medicine of the Austrian Academy ofEmail được xác minh tại cemm.oeaw.ac.at
Stephen RagsdaleUniversity of MichiganEmail được xác minh tại umich.edu
James BradnerAmgen | EVP R&D and CSO

Theo dõi

John R. Engen

James L. Waters Chair & Distinguished Professor of Chemistry, Northeastern University

Email được xác minh tại neu.edu - Trang chủ

Protein conformation mass spectrometry hydrogen exchange HDX-MS


Tiêu đề Sắp xếp theo số lượt trích dẫn Sắp xếp theo năm Sắp xếp theo tiêu đề	Trích dẫn bởi Trích dẫn bởi	Năm
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ... Nature 462 (7276), 1070-1074, 2009	1198	2009
Hydrogen exchange mass spectrometry for the analysis of protein dynamics TE Wales, JR Engen Mass spectrometry reviews 25 (1), 158-170, 2006	1008	2006
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ... Nature 463 (7280), 501-506, 2010	716	2010
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ... Nature Methods 16 (7), 595-602, 2019	645	2019
Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars SA Berkowitz, JR Engen, JR Mazzeo, GB Jones Nature Reviews Drug Discovery 11 (7), 527-540, 2012	631	2012
Post-translational modifications differentially affect IgG1 conformation and receptor binding D Houde, Y Peng, SA Berkowitz, JR Engen Molecular & Cellular Proteomics 9 (8), 1716-1728, 2010	475	2010
Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS JR Engen Analytical chemistry 81 (19), 7870-7875, 2009	459	2009
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies D Houde, SA Berkowitz, JR Engen Journal of pharmaceutical sciences 100 (6), 2071-2086, 2011	402	2011
High-speed and high-resolution UPLC separation at zero degrees Celsius TE Wales, KE Fadgen, GC Gerhardt, JR Engen Analytical chemistry 80 (17), 6815-6820, 2008	391	2008
Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ... Angewandte Chemie International Edition 53 (1), 199-204, 2014	372	2014
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome Y Shi, X Chen, S Elsasser, BB Stocks, G Tian, BH Lee, Y Shi, N Zhang, ... Science 351 (6275), aad9421, 2016	325	2016
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature Communications 3, 1288, 2012	308	2012
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express DD Weis, JR Engen, IJ Kass Journal of the American Society for Mass Spectrometry 17, 1700-1703, 2006	303	2006
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding EC Twomey, Z Ji, TE Wales, NO Bodnar, SB Ficarro, JA Marto, JR Engen, ... Science 365 (6452), eaax1033, 2019	289	2019
Investigating Protein Structure and Dynamics by Hydrogen Exchange MS JR Engen, DL Smith Analytical chemistry 73 (9), 256-265, 2001	289	2001
Force interacts with macromolecular structure in activation of TGF-β X Dong, B Zhao, RE Iacob, J Zhu, AC Koksal, C Lu, JR Engen, ... Nature 542 (7639), 55-59, 2017	282	2017
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry D Houde, J Arndt, W Domeier, S Berkowitz, JR Engen Analytical chemistry 81 (7), 2644-2651, 2009	281	2009
Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis DD Weis, TE Wales, JR Engen, M Hotchko, LF Ten Eyck Journal of the American Society for Mass Spectrometry 17, 1498-1509, 2006	263	2006
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice R Mourtada, HD Herce, DJ Yin, JA Moroco, TE Wales, JR Engen, ... Nature Biotechnology 37 (10), 1186-1197, 2019	244	2019
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications H Wei, J Mo, L Tao, RJ Russell, AA Tymiak, G Chen, RE Iacob, JR Engen Drug discovery today 19 (1), 95-102, 2014	240	2014

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