| JASPAR: an open‐access database for eukaryotic transcription factor binding profiles A Sandelin, W Alkema, P Engström, WW Wasserman, B Lenhard Nucleic acids research 32 (suppl_1), D91-D94, 2004 | 2225 | 2004 |
| BioVenn–a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams T Hulsen, J de Vlieg, W Alkema BMC genomics 9, 1-6, 2008 | 1709 | 2008 |
| Genome-wide analysis of mammalian promoter architecture and evolution P Carninci, A Sandelin, B Lenhard, S Katayama, K Shimokawa, ... Nature genetics 38 (6), 626-635, 2006 | 1674 | 2006 |
| Quantifying the accessibility of the metagenome by random expression cloning techniques EM Gabor, WBL Alkema, DB Janssen Environmental microbiology 6 (9), 879-886, 2004 | 350 | 2004 |
| Application of text mining in the biomedical domain WWM Fleuren, W Alkema Methods 74, 97-106, 2015 | 239 | 2015 |
| Literature mining for the discovery of hidden connections between drugs, genes and diseases R Frijters, M Van Vugt, R Smeets, R Van Schaik, J De Vlieg, W Alkema PLoS computational biology 6 (9), e1000943, 2010 | 189 | 2010 |
| High-throughput screening of a large collection of non-conventional yeasts reveals their potential for aroma formation in food fermentation A Gamero, R Quintilla, M Groenewald, W Alkema, T Boekhout, ... Food Microbiology 60, 147-159, 2016 | 143 | 2016 |
| Identification of functional clusters of transcription factor binding motifs in genome sequences: the MSCAN algorithm Ö Johansson, W Alkema, WW Wasserman, J Lagergren Bioinformatics 19 (suppl_1), i169-i176, 2003 | 123 | 2003 |
| Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor R Frijters, W Fleuren, EJM Toonen, JP Tuckermann, HM Reichardt, ... BMC genomics 11, 1-14, 2010 | 121 | 2010 |
| The role of hydrophobic active‐site residues in substrate specificity and acyl transfer activity of penicillin acylase WBL Alkema, AJ Dijkhuis, E De Vries, DB Janssen European journal of biochemistry 269 (8), 2093-2100, 2002 | 115 | 2002 |
| Characterization of the β-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies WBL Alkema, CMH Hensgens, EH Kroezinga, E De Vries, R Floris, ... Protein Engineering 13 (12), 857-863, 2000 | 111 | 2000 |
| CoPub: a literature-based keyword enrichment tool for microarray data analysis R Frijters, B Heupers, P van Beek, M Bouwhuis, R van Schaik, J de Vlieg, ... Nucleic acids research 36 (suppl_2), W406-W410, 2008 | 104 | 2008 |
| MSCAN: identification of functional clusters of transcription factor binding sites WBL Alkema, Ö Johansson, J Lagergren, WW Wasserman Nucleic acids research 32 (suppl_2), W195-W198, 2004 | 91 | 2004 |
| Microbial bioinformatics for food safety and production W Alkema, J Boekhorst, M Wels, SAFT van Hijum Briefings in bioinformatics 17 (2), 283-292, 2016 | 89 | 2016 |
| Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells MML Linssen, DH Van Raalte, EJM Toonen, W Alkema, GC Van der Zon, ... Cellular signalling 23 (11), 1708-1715, 2011 | 85 | 2011 |
| Live biotherapeutic products, a road map for safety assessment A Rouanet, S Bolca, A Bru, I Claes, H Cvejic, H Girgis, A Harper, ... Frontiers in Medicine 7, 237, 2020 | 80 | 2020 |
| Regulog analysis: detection of conserved regulatory networks across bacteria: application to Staphylococcus aureus WBL Alkema, B Lenhard, WW Wasserman Genome research 14 (7), 1362-1373, 2004 | 80 | 2004 |
| Magnesium prevents vascular calcification in Klotho deficiency AD Ter Braake, AE Smit, C Bos, AE van Herwaarden, W Alkema, ... Kidney international 97 (3), 487-501, 2020 | 76 | 2020 |
| Hydrogenosomes in the anaerobic fungus Neocallimastix frontalis have a double membrane but lack an associated organelle genome M Van Der Giezen, KA Sjollema, RRE Artz, W Alkema, RA Prins FEBS letters 408 (2), 147-150, 1997 | 76 | 1997 |
| Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling RL Smeets, WWM Fleuren, X He, PM Vink, F Wijnands, M Gorecka, ... BMC immunology 13, 1-17, 2012 | 73 | 2012 |
