Converting peptides into drugs targeting intracellular protein–protein interactions GJB Philippe, DJ Craik, ST Henriques Drug Discovery Today 26 (6), 1521-1531, 2021 | 82 | 2021 |
Development of cell‐penetrating peptide‐based drug leads to inhibit MDMX: p53 and MDM2: p53 interactions G Philippe, YH Huang, O Cheneval, N Lawrence, Z Zhang, DP Fairlie, ... Peptide Science 106 (6), 853-863, 2016 | 28 | 2016 |
Angler peptides: macrocyclic conjugates inhibit p53: MDM2/X interactions and activate apoptosis in cancer cells GJB Philippe, A Mittermeier, N Lawrence, YH Huang, ND Condon, ... ACS chemical biology 16 (2), 414-428, 2021 | 24 | 2021 |
Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells N Lawrence, GJB Philippe, PJ Harvey, ND Condon, AH Benfield, ... RSC Chemical Biology 1 (5), 405-420, 2020 | 20 | 2020 |
Cell membrane composition drives selectivity and toxicity of designed cyclic helix–loop–helix peptides with cell penetrating and tumor suppressor properties GJB Philippe, D Gaspar, C Sheng, YH Huang, AH Benfield, ND Condon, ... ACS Chemical Biology 14 (9), 2071-2087, 2019 | 20 | 2019 |
Delivery to, and reactivation of, the p53 pathway in cancer cells using a grafted cyclotide conjugated with a cell-penetrating peptide GJB Philippe, YH Huang, A Mittermeier, CJ Brown, Q Kaas, SR Ramlan, ... Journal of medicinal chemistry 67 (2), 1197-1208, 2024 | 10 | 2024 |
Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake G Philippe, YH Huang, A Mittermeier, C Brown, C Wang, Q Kaas, ... Journal of Peptide Science 28, 2022 | | 2022 |
Development of peptide-based anti-cancer drugs targeting intracellular protein-protein interactions GJB Philippe | | 2020 |