Sensitive red protein calcium indicators for imaging neural activity H Dana, B Mohar, Y Sun, S Narayan, A Gordus, JP Hasseman, ...
Elife 5, e12727, 2016
1069 2016 Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals J de Juan-Sanz, GT Holt, ER Schreiter, F de Juan, DS Kim, TA Ryan
Neuron 93 (4), 867-881. e6, 2017
267 2017 Improved methods for marking active neuron populations B Moeyaert, G Holt, R Madangopal, A Perez-Alvarez, BC Fearey, ...
Nature communications 9 (1), 1-12, 2018
155 2018 A low affinity GCaMP3 variant (GCaMPer) for imaging the endoplasmic reticulum calcium store MJ Henderson, HA Baldwin, CA Werley, S Boccardo, LR Whitaker, X Yan, ...
PLoS One 10 (10), e0139273, 2015
89 2015 OSPREY 3.0: Open‐source protein redesign for you, with powerful new features MA Hallen, JW Martin, A Ojewole, JD Jou, AU Lowegard, MS Frenkel, ...
Journal of Computational Chemistry 39 (30), 2494-2507, 2018
80 2018 Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ...
ACS infectious diseases 5 (11), 1896-1906, 2019
22 2019 Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD: KRas protein-protein interface AU Lowegard, MS Frenkel, GT Holt, JD Jou, AA Ojewole, BR Donald
PLOS Computational Biology 16 (6), e1007447, 2020
16 2020 Minimization-Aware Recursive K*: A Novel, Provable Algorithm that Accelerates Ensemble-Based Protein Design and Provably Approximates the Energy Landscape JD Jou, GT Holt, AU Lowegard, BR Donald
Journal of Computational Biology 27 (4), 550-564, 2020
12 2020 Computational analysis of energy landscapes reveals dynamic features that contribute to binding of inhibitors to CFTR-associated ligand GT Holt, JD Jou, NP Gill, AU Lowegard, JW Martin, DR Madden, ...
The Journal of Physical Chemistry B 123 (49), 10441-10455, 2019
11 2019 Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design GT Holt, J Gorman, S Wang, AU Lowegard, B Zhang, T Liu, BC Lin, ...
Cell Reports 42 (7), 112711, 2023
10 2023 Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus S Wang, SM Reeve, GT Holt, AA Ojewole, MS Frenkel, P Gainza, ...
PLoS computational biology 18 (2), e1009855, 2022
10 2022 PINDER: The protein interaction dataset and evaluation resource D Kovtun, M Akdel, A Goncearenco, G Zhou, G Holt, D Baugher, D Lin, ...
bioRxiv, 2024.07. 17.603980, 2024
5 2024 Minimization-Aware Recursive JD Jou, GT Holt, AU Lowegard, BR Donald
Research in Computational Molecular Biology: 23rd Annual International …, 2019
3 2019 Bending and Binding: Predicting Protein Flexibility upon Ligand Interaction using Diffusion Models X Zhang, T Geffner, M McPartlon, M Akdel, D Abramson, G Holt, ...
NeurIPS 2023 Generative AI and Biology (GenBio) Workshop, 2023
2 2023 Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ...
ACS infectious diseases 5 (11), 1896, 2019
2 2019 Improved red protein indicators for in vivo calcium imaging H Dana, Y Sun, JP Hasseman, G Tsegaye, GT Holt, BF Fosque, ...
Program#/Poster 566, 2014
2 2014 Ensemble-based Computational Protein Design: Novel Algorithms and Applications to Energy Landscape Approximation, Antibiotic Resistance, and Antibody Design GT Holt
Duke University, 2022
2022