| β-Lactamases and β-lactamase inhibitors in the 21st century CL Tooke, P Hinchliffe, EC Bragginton, CK Colenso, VHA Hirvonen, ... Journal of molecular biology 431 (18), 3472-3500, 2019 | 1033 | 2019 |
| Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus LA Sazanov, P Hinchliffe Science 311 (5766), 1430-1436, 2006 | 960 | 2006 |
| Organization of iron-sulfur clusters in respiratory complex I P Hinchliffe, LA Sazanov Science 309 (5735), 771-774, 2005 | 259 | 2005 |
| Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms Q Yang, M Li, OB Spiller, DO Andrey, P Hinchliffe, H Li, C MacLean, ... Nature Communications 8 (1), 2054, 2017 | 194 | 2017 |
| Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases A Krajnc, J Brem, P Hinchliffe, K Calvopiña, TD Panduwawala, PA Lang, ... Journal of medicinal chemistry 62 (18), 8544-8556, 2019 | 187 | 2019 |
| Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1 P Hinchliffe, QE Yang, E Portal, T Young, H Li, CL Tooke, MJ Carvalho, ... Scientific reports 7, 39392, 2017 | 154 | 2017 |
| Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes P Hinchliffe, MM González, MF Mojica, JM González, V Castillo, C Saiz, ... Proceedings of the National Academy of Sciences 113 (26), E3745-E3754, 2016 | 151 | 2016 |
| Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase MM González, M Kosmopoulou, MF Mojica, V Castillo, P Hinchliffe, ... ACS Infectious Diseases 1 (11), 544-554, 2015 | 122 | 2015 |
| Structure and operation of bacterial tripartite pumps P Hinchliffe, MF Symmons, C Hughes, V Koronakis Annual review of microbiology 67 (1), 221-242, 2013 | 103 | 2013 |
| Structures of sequential open states in a symmetrical opening transition of the TolC exit duct XY Pei, P Hinchliffe, MF Symmons, E Koronakis, R Benz, C Hughes, ... Proceedings of the National Academy of Sciences 108 (5), 2112-2117, 2011 | 100 | 2011 |
| Identification of a novel subunit of respiratory complex I from Thermus thermophilus P Hinchliffe, J Carroll, LA Sazanov Biochemistry 45 (14), 4413-4420, 2006 | 89 | 2006 |
| Molecular basis of class A β-lactamase inhibition by relebactam CL Tooke, P Hinchliffe, PA Lang, AJ Mulholland, J Brem, CJ Schofield, ... Antimicrobial agents and chemotherapy 63 (10), 10.1128/aac. 00564-19, 2019 | 71 | 2019 |
| Structural and kinetic studies of the potent inhibition of metallo-β-lactamases by 6-phosphonomethylpyridine-2-carboxylates P Hinchliffe, CA Tanner, AP Krismanich, G Labbé, VJ Goodfellow, ... Biochemistry 57 (12), 1880-1892, 2018 | 69 | 2018 |
| Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump P Hinchliffe, NP Greene, NG Paterson, A Crow, C Hughes, V Koronakis FEBS letters 588 (17), 3147-3153, 2014 | 61 | 2014 |
| Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ... Nature Chemistry 14 (1), 15-24, 2022 | 57 | 2022 |
| An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography A Butryn, PS Simon, P Aller, P Hinchliffe, RN Massad, G Leen, CL Tooke, ... Nature communications 12 (1), 4461, 2021 | 51 | 2021 |
| Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography P Kamsri, C Hanwarinroj, N Phusi, T Pornprom, K Chayajarus, ... Journal of Chemical Information and Modeling 60 (1), 226-234, 2019 | 51 | 2019 |
| Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates K Calvopiña, P Hinchliffe, J Brem, KJ Heesom, S Johnson, R Cain, ... Molecular Microbiology 106 (3), 492-504, 2017 | 51 | 2017 |
| Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. CT Lohans, EI Freeman, EV Groesen, CL Tooke, P Hinchliffe, J Spencer, ... Scientific reports 9 (1), 13608-13608, 2019 | 50 | 2019 |
| Profiling interactions of vaborbactam with metallo-β-lactamases GW Langley, R Cain, JM Tyrrell, P Hinchliffe, K Calvopiña, CL Tooke, ... Bioorganic & medicinal chemistry letters 29 (15), 1981-1984, 2019 | 44 | 2019 |
Catherine L. TookeUniversity of BathEmail được xác minh tại bristol.ac.uk