Characterization of 2′-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion A Rhie, L Kirby, N Sayer, R Wellesley, P Disterer, I Sylvester, A Gill, ... Journal of Biological Chemistry 278 (41), 39697-39705, 2003 | 256 | 2003 |
Delivery is key: lessons learnt from developing splice‐switching antisense therapies C Godfrey, LR Desviat, B Smedsrød, F Piétri‐Rouxel, MA Denti, P Disterer, ... EMBO molecular medicine 9 (5), 545-557, 2017 | 171 | 2017 |
Pathogenetic mechanisms of amyloid A amyloidosis JP Simons, R Al-Shawi, S Ellmerich, I Speck, S Aslam, WL Hutchinson, ... Proceedings of the National Academy of Sciences 110 (40), 16115-16120, 2013 | 128 | 2013 |
Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant: implications for disease susceptibility to Creutzfeldt-Jakob disease A Tahiri-Alaoui, AC Gill, P Disterer, W James Journal of Biological Chemistry 279 (30), 31390-31397, 2004 | 92 | 2004 |
Development of therapeutic splice-switching oligonucleotides P Disterer, A Kryczka, Y Liu, YE Badi, JJ Wong, JS Owen, B Khoo Human gene therapy 25 (7), 587-598, 2014 | 76 | 2014 |
Multigene RNA vector based on coronavirus transcription V Thiel, N Karl, B Schelle, P Disterer, I Klagge, SG Siddell Journal of virology 77 (18), 9790-9798, 2003 | 60 | 2003 |
The presence of valine at residue 129 in human prion protein accelerates amyloid formation I Baskakov, P Disterer, L Breydo, M Shaw, A Gill, W James, ... FEBS letters 579 (12), 2589-2596, 2005 | 55 | 2005 |
Use of internally nuclease‐protected single‐strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells … I Papaioannou, P Disterer, JS Owen The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2009 | 43 | 2009 |
Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo P Disterer, R Al-Shawi, S Ellmerich, SN Waddington, JS Owen, JP Simons, ... Molecular Therapy 21 (3), 602-609, 2013 | 39 | 2013 |
Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation A Theodoraki, Y Hu, S Poopalasundaram, A Oosterhof, SE Guimond, ... Molecular and cellular endocrinology 399, 296-310, 2015 | 28 | 2015 |
Validation of oligonucleotide-mediated gene editing P Disterer, JP Simons, JS Owen Gene Therapy 16 (6), 824-826, 2009 | 9 | 2009 |
Antisense-mediated exon-skipping to induce gene knockdown P Disterer, B Khoo Exon Skipping: Methods and Protocols, 289-305, 2012 | 8 | 2012 |
Oligonucleotide‐mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression P Disterer, I Papaioannou, VC Evans, J Paul Simons, JS Owen The journal of gene medicine 14 (2), 109-119, 2012 | 5 | 2012 |
PROTEIN STRUCTURE AND FOLDING-Characterization of 2'-Fluoro-RNA Aptamers That Bind Preferentially to Disease-associated Conformations of Prion Protein and Inhibit Conversion. A Rhie, L Kirby, N Sayer, R Wellesley, P Disterer, I Sylvester, A Gill, ... Journal of Biological Chemistry 278 (41), 39697-39705, 2003 | 3 | 2003 |
Gene Therapy for Apolipoprotein AI and HDL—The Ultimate Treatment for Atherosclerosis P Disterer, E Osman, JS Owen Vascular Complications in Human Disease: Mechanisms and Consequences, 197-212, 2008 | 1 | 2008 |
Gene therapy for apolipoprotein AI and HDL-the ultimate treatment for atherosclerosis P Disterer, E Osman, JS Owen Springer Verlag, 2007 | 1 | 2007 |
Dieter C. Gruenert, PhD (1949–2016) P Disterer, MA Kay, GC Parker Nucleic Acid Therapeutics 26 (4), 266-267, 2016 | | 2016 |
APO-skip splice-switching oligonucleotides to treat familial hypercholesterolemia P Disterer, JP Simons, JS Owen, B Khoo HUMAN GENE THERAPY 24 (5), A31-A31, 2013 | | 2013 |
Altered sulfation patterns of heparan sulfate on FGFR1 signalling in INS1 cells A Theodoraki, Y Hu, S Poopalasundaram, S Guimond, A Oosterhof, ... DIABETIC MEDICINE 30, 33-34, 2013 | | 2013 |
British Society for Gene and Cell Therapy (BSGCT) Conference Abstracts Royal Holloway University of London 17–19 April, 2013 C Denning, GM Ellison, K Mitrophanous, L Seymour, JCI Belmonte, ... | | 2013 |