| CRISPR-engineered T cells in patients with refractory cancer EA Stadtmauer, JA Fraietta, MM Davis, AD Cohen, KL Weber, E Lancaster, ... Science 367 (6481), eaba7365, 2020 | 1345 | 2020 |
| Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition J Ren, X Liu, C Fang, S Jiang, CH June, Y Zhao Clinical cancer research 23 (9), 2255-2266, 2017 | 984 | 2017 |
| Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies GL Beatty, AR Haas, MV Maus, DA Torigian, MC Soulen, G Plesa, ... Cancer immunology research 2 (2), 112-120, 2014 | 974 | 2014 |
| Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells JA Fraietta, CL Nobles, MA Sammons, S Lundh, SA Carty, TJ Reich, ... Nature 558 (7709), 307-312, 2018 | 812 | 2018 |
| T cells expressing chimeric antigen receptors can cause anaphylaxis in humans MV Maus, AR Haas, GL Beatty, SM Albelda, BL Levine, X Liu, Y Zhao, ... Cancer immunology research 1 (1), 26-31, 2013 | 708 | 2013 |
| Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice X Liu, S Jiang, C Fang, S Yang, D Olalere, EC Pequignot, AP Cogdill, N Li, ... Cancer research 75 (17), 3596-3607, 2015 | 617 | 2015 |
| Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability CJ Cohen, Y Zhao, Z Zheng, SA Rosenberg, RA Morgan Cancer research 66 (17), 8878-8886, 2006 | 617 | 2006 |
| Dominant-negative TGF-β receptor enhances PSMA-targeted human CAR T cell proliferation and augments prostate cancer eradication CC Kloss, J Lee, A Zhang, F Chen, JJ Melenhorst, SF Lacey, MV Maus, ... Molecular therapy 26 (7), 1855-1866, 2018 | 588 | 2018 |
| Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor JN Kochenderfer, SA Feldman, Y Zhao, H Xu, MA Black, RA Morgan, ... Journal of immunotherapy 32 (7), 689-702, 2009 | 568 | 2009 |
| A chimeric switch-receptor targeting PD1 augments the efficacy of second-generation CAR T cells in advanced solid tumors X Liu, R Ranganathan, S Jiang, C Fang, J Sun, S Kim, K Newick, A Lo, ... Cancer research 76 (6), 1578-1590, 2016 | 546 | 2016 |
| Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor Y Zhao, E Moon, C Carpenito, CM Paulos, X Liu, AL Brennan, A Chew, ... Cancer research 70 (22), 9053-9061, 2010 | 519 | 2010 |
| Augmentation of antitumor immunity by human and mouse CAR T cells secreting IL-18 B Hu, J Ren, Y Luo, B Keith, RM Young, J Scholler, Y Zhao, CH June Cell reports 20 (13), 3025-3033, 2017 | 458 | 2017 |
| Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions PF Robbins, YF Li, M El-Gamil, Y Zhao, JA Wargo, Z Zheng, H Xu, ... The Journal of Immunology 180 (9), 6116-6131, 2008 | 444 | 2008 |
| Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer J Tchou, Y Zhao, BL Levine, PJ Zhang, MM Davis, JJ Melenhorst, ... Cancer immunology research 5 (12), 1152-1161, 2017 | 432 | 2017 |
| A versatile system for rapid multiplex genome-edited CAR T cell generation J Ren, X Zhang, X Liu, C Fang, S Jiang, CH June, Y Zhao Oncotarget 8 (10), 17002, 2017 | 432 | 2017 |
| A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity Y Zhao, QJ Wang, S Yang, JN Kochenderfer, Z Zheng, X Zhong, ... The Journal of Immunology 183 (9), 5563-5574, 2009 | 426 | 2009 |
| High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation Y Zhao, Z Zheng, CJ Cohen, L Gattinoni, DC Palmer, NP Restifo, ... Molecular therapy 13 (1), 151-159, 2006 | 368 | 2006 |
| Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells MJ Frigault, J Lee, MC Basil, C Carpenito, S Motohashi, J Scholler, ... Cancer immunology research 3 (4), 356-367, 2015 | 358 | 2015 |
| Adoptive immunotherapy for cancer or viruses MV Maus, JA Fraietta, BL Levine, M Kalos, Y Zhao, CH June Annual review of immunology 32 (1), 189-225, 2014 | 340 | 2014 |
| Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice D Chinnasamy, Z Yu, MR Theoret, Y Zhao, RK Shrimali, RA Morgan, ... The Journal of clinical investigation 120 (11), 3953-3968, 2010 | 298 | 2010 |
Carl JuneUniversity of PennsylvaniaEmail được xác minh tại upenn.edu