| Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis JE Chipuk, GP McStay, A Bharti, T Kuwana, CJ Clarke, LJ Siskind, ... Cell 148 (5), 988-1000, 2012 | 488 | 2012 |
| Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation J Wei, M Ferron, CJ Clarke, YA Hannun, H Jiang, WS Blaner, G Karsenty The Journal of clinical investigation 124 (4), 1781-1793, 2014 | 301 | 2014 |
| Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 D Kajimura, HW Lee, KJ Riley, E Arteaga-Solis, M Ferron, B Zhou, ... Cell metabolism 17 (6), 901-915, 2013 | 248 | 2013 |
| Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids D Milhas, CJ Clarke, YA Hannun FEBS letters 584 (9), 1887-1894, 2010 | 241 | 2010 |
| The extended family of neutral sphingomyelinases CJ Clarke, CF Snook, M Tani, N Matmati, N Marchesini, YA Hannun Biochemistry 45 (38), 11247-11256, 2006 | 214 | 2006 |
| Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses BX Wu, CJ Clarke, YA Hannun Neuromolecular medicine 12, 320-330, 2010 | 197 | 2010 |
| Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5 BX Wu, V Rajagopalan, PL Roddy, CJ Clarke, YA Hannun Journal of Biological Chemistry 285 (23), 17993-18002, 2010 | 155 | 2010 |
| The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis LJ Siskind, TD Mullen, KR Rosales, CJ Clarke, MJ Hernandez-Corbacho, ... Journal of Biological Chemistry 285 (16), 11818-11826, 2010 | 155 | 2010 |
| Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in … CJ Clarke, TG Truong, YA Hannun Journal of Biological Chemistry 282 (2), 1384-1396, 2007 | 143 | 2007 |
| Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events TD Mullen, RW Jenkins, CJ Clarke, J Bielawski, YA Hannun, LM Obeid Journal of Biological Chemistry 286 (18), 15929-15942, 2011 | 126 | 2011 |
| Neutral sphingomyelinases and nSMase2: bridging the gaps CJ Clarke, YA Hannun Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (12), 1893-1901, 2006 | 116 | 2006 |
| A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization Z Khavandgar, C Poirier, CJ Clarke, J Li, N Wang, MD McKee, ... Journal of Cell Biology 194 (2), 277-289, 2011 | 102 | 2011 |
| The neutral sphingomyelinase family: identifying biochemical connections CJ Clarke, BX Wu, YA Hannun Advances in enzyme regulation 51 (1), 51-58, 2011 | 91 | 2011 |
| Role of neutral ceramidase in colon cancer M García-Barros, N Coant, T Kawamori, M Wada, AJ Snider, JP Truman, ... The FASEB Journal 30 (12), 4159, 2016 | 84 | 2016 |
| Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-α involves protein kinase C-δ in lung epithelial cells CJ Clarke, JM Guthrie, YA Hannun Molecular pharmacology 74 (4), 1022-1032, 2008 | 84 | 2008 |
| A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing RW Jenkins, J Idkowiak-Baldys, F Simbari, D Canals, P Roddy, CD Riner, ... Journal of Biological Chemistry 286 (5), 3777-3788, 2011 | 75 | 2011 |
| P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest AA Shamseddine, CJ Clarke, B Carroll, MV Airola, S Mohammed, A Rella, ... Cell death & disease 6 (10), e1947-e1947, 2015 | 73 | 2015 |
| Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells CJ Clarke, EA Cloessner, PL Roddy, YA Hannun Biochemical Journal 435 (2), 381-390, 2011 | 71 | 2011 |
| Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane D Milhas, CJ Clarke, J Idkowiak-Baldys, D Canals, YA Hannun Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2010 | 71 | 2010 |
| Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis S Rachidi, S Sun, BX Wu, E Jones, RR Drake, B Ogretmen, LA Cowart, ... Journal of hepatology 62 (4), 879-888, 2015 | 67 | 2015 |
