The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair PC Fineran, TR Blower, IJ Foulds, DP Humphreys, KS Lilley, ... Proceedings of the National Academy of Sciences 106 (3), 894-899, 2009 | 715 | 2009 |
Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis TR Blower, BH Williamson, RJ Kerns, JM Berger Proceedings of the National Academy of Sciences 113 (7), 1706-1713, 2016 | 218 | 2016 |
Identification and classification of bacterial Type III toxin–antitoxin systems encoded in chromosomal and plasmid genomes TR Blower, FL Short, F Rao, K Mizuguchi, XY Pei, PC Fineran, BF Luisi, ... Nucleic acids research 40 (13), 6158-6173, 2012 | 197 | 2012 |
A processed noncoding RNA regulates an altruistic bacterial antiviral system TR Blower, XY Pei, FL Short, PC Fineran, DP Humphreys, BF Luisi, ... Nature structural & molecular biology 18 (2), 185-190, 2011 | 187 | 2011 |
Viral evasion of a bacterial suicide system by RNA–based molecular mimicry enables infectious altruism TR Blower, TJ Evans, R Przybilski, PC Fineran, GPC Salmond Public Library of Science 8 (10), e1003023, 2012 | 147 | 2012 |
Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin–antitoxin partners TR Blower, GPC Salmond, BF Luisi Current opinion in structural biology 21 (1), 109-118, 2011 | 110 | 2011 |
Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia TR Blower, PC Fineran, MJ Johnson, IK Toth, DP Humphreys, ... Journal of bacteriology 191 (19), 6029-6039, 2009 | 105 | 2009 |
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase KJ Aldred, TR Blower, RJ Kerns, JM Berger, N Osheroff Proceedings of the National Academy of Sciences 113 (7), E839-E846, 2016 | 102 | 2016 |
Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot FL Short, XY Pei, TR Blower, SL Ong, PC Fineran, BF Luisi, ... Proceedings of the National Academy of Sciences 110 (3), E241-E249, 2013 | 98 | 2013 |
The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses DM Picton, YA Luyten, RD Morgan, A Nelson, DL Smith, DTF Dryden, ... Nucleic acids research 49 (19), 11257-11273, 2021 | 72 | 2021 |
Evolution of Pectobacterium bacteriophage ΦM1 to escape two bifunctional type III toxin-antitoxin and abortive infection systems through mutations in a single viral gene TR Blower, R Chai, R Przybilski, S Chindhy, X Fang, SE Kidman, H Tan, ... Applied and environmental microbiology 83 (8), e03229-16, 2017 | 44 | 2017 |
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems Y Cai, B Usher, C Gutierrez, A Tolcan, M Mansour, PC Fineran, C Condon, ... Science advances 6 (31), eabb6651, 2020 | 43 | 2020 |
Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection A Kelly, TJ Arrowsmith, SC Went, TR Blower Current Opinion in Microbiology 73, 102293, 2023 | 36 | 2023 |
A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands DM Picton, JD Harling-Lee, SJ Duffner, SC Went, RD Morgan, JCD Hinton, ... Nucleic Acids Research 50 (9), 5191-5207, 2022 | 34 | 2022 |
Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons EG Gibson, TR Blower, M Cacho, B Bax, JM Berger, N Osheroff ACS infectious diseases 4 (8), 1211-1222, 2018 | 34 | 2018 |
AbiEi binds cooperatively to the type IV abiE toxin–antitoxin operator via a positively-charged surface and causes DNA bending and negative autoregulation HG Hampton, SA Jackson, RD Fagerlund, AIM Vogel, RL Dy, TR Blower, ... Journal of molecular biology 430 (8), 1141-1156, 2018 | 33 | 2018 |
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase RE Ashley, TR Blower, JM Berger, N Osheroff Biochemistry 56 (40), 5440-5448, 2017 | 29 | 2017 |
Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein–RNA toxin–antitoxin system F Rao, FL Short, JE Voss, TR Blower, AL Orme, TE Whittaker, BF Luisi, ... Nucleic Acids Research 43 (19), 9529-9540, 2015 | 29 | 2015 |
Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase Inhibitors JM Cross, TR Blower, N Gallagher, JH Gill, KL Rockley, JW Walton ChemPlusChem 81 (12), 1276-1280, 2016 | 28 | 2016 |
Conserved domains can be found across distinct phage defence systems G Mariano, TR Blower Molecular microbiology 120 (1), 45-53, 2023 | 19 | 2023 |