| Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics AS Nam, R Chaligne, DA Landau Nature Reviews Genetics 22 (1), 3-18, 2021 | 345 | 2021 |
| Somatic mutations and cell identity linked by Genotyping of Transcriptomes AS Nam, KT Kim, R Chaligne, F Izzo, C Ang, J Taylor, RM Myers, ... Nature 571 (7765), 355-360, 2019 | 304 | 2019 |
| Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia F Gaiti, R Chaligne, H Gu, RM Brand, S Kothen-Hill, RC Schulman, ... Nature 569 (7757), 576-580, 2019 | 250 | 2019 |
| DNA methylation disruption reshapes the hematopoietic differentiation landscape F Izzo, SC Lee, A Poran, R Chaligne, F Gaiti, B Gross, RR Murali, ... Nature genetics 52 (4), 378-387, 2020 | 231 | 2020 |
| Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling JM Chan, S Zaidi, JR Love, JL Zhao, M Setty, KM Wadosky, A Gopalan, ... Science 377 (6611), 1180-1191, 2022 | 202 | 2022 |
| Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states R Chaligne, F Gaiti, D Silverbush, JS Schiffman, HR Weisman, L Kluegel, ... Nature genetics 53 (10), 1469-1479, 2021 | 176 | 2021 |
| X-chromosome inactivation in development and cancer R Chaligné, E Heard FEBS letters 588 (15), 2514-2522, 2014 | 164 | 2014 |
| The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer R Chaligné, T Popova, MA Mendoza-Parra, MAM Saleem, D Gentien, ... Genome research 25 (4), 488-503, 2015 | 161 | 2015 |
| New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition R Chaligné, C Tonetti, R Besancenot, L Roy, C Marty, P Mossuz, ... Leukemia 22 (8), 1557-1566, 2008 | 150 | 2008 |
| Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis R Chaligné, C James, C Tonetti, R Besancenot, JP Le Couédic, F Fava, ... Blood 110 (10), 3735-3743, 2007 | 128 | 2007 |
| The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity C James, F Mazurier, S Dupont, R Chaligne, I Lamrissi-Garcia, M Tulliez, ... Blood 112 (6), 2429-2438, 2008 | 124 | 2008 |
| A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation R Besancenot, R Chaligné, C Tonetti, F Pasquier, C Marty, Y Lécluse, ... PLoS biology 8 (9), e1000476, 2010 | 122 | 2010 |
| Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor C Pecquet, J Staerk, R Chaligné, V Goss, KA Lee, X Zhang, J Rush, ... Blood 115 (5), 1037-1048, 2010 | 98 | 2010 |
| SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data S Persad, ZN Choo, C Dien, N Sohail, I Masilionis, R Chaligné, T Nawy, ... Nature Biotechnology 41 (12), 1746-1757, 2023 | 96 | 2023 |
| Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis C Burdziak, D Alonso-Curbelo, T Walle, J Reyes, FM Barriga, D Haviv, ... Science 380 (6645), eadd5327, 2023 | 93 | 2023 |
| Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation AS Nam, N Dusaj, F Izzo, R Murali, RM Myers, TH Mouhieddine, J Sotelo, ... Nature genetics 54 (10), 1514-1526, 2022 | 91 | 2022 |
| Anatomic position determines oncogenic specificity in melanoma JM Weiss, MV Hunter, NM Cruz, A Baggiolini, M Tagore, Y Ma, S Misale, ... Nature 604 (7905), 354-361, 2022 | 80 | 2022 |
| Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL A Pastore, F Gaiti, SX Lu, RM Brand, S Kulm, R Chaligne, H Gu, ... Nature communications 10 (1), 1874, 2019 | 78 | 2019 |
| MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis FM Barriga, KM Tsanov, YJ Ho, N Sohail, A Zhang, T Baslan, AN Wuest, ... Nature Cancer 3 (11), 1367-1385, 2022 | 76 | 2022 |
| Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice O Wagner-Ballon, DF Pisani, T Gastinne, M Tulliez, R Chaligné, C Lacout, ... Blood 110 (1), 345-353, 2007 | 61 | 2007 |
Dan-Avi Landau, MD, PhDAssociate Professor, Weill Cornell Medicine & Core Member, NY Genome Center在 nygenome.org 的电子邮件经过验证