Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses FS Varghese, P Kaukinen, S Gläsker, M Bespalov, L Hanski, ... Antiviral research 126, 117-124, 2016 | 246 | 2016 |
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 212 | 2022 |
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase signaling FS Varghese, B Thaa, SN Amrun, D Simarmata, K Rausalu, TA Nyman, ... Journal of virology 90 (21), 9743-9757, 2016 | 155 | 2016 |
Differential phosphatidylinositol-3-kinase-Akt-mTOR activation by Semliki Forest and chikungunya viruses is dependent on nsP3 and connected to replication complex internalization B Thaa, R Biasiotto, K Eng, M Neuvonen, B Götte, L Rheinemann, ... Journal of virology 89 (22), 11420-11437, 2015 | 119 | 2015 |
Design and validation of novel chikungunya virus protease inhibitors PK Das, L Puusepp, FS Varghese, A Utt, T Ahola, DG Kananovich, ... Antimicrobial agents and chemotherapy 60 (12), 7382-7395, 2016 | 78 | 2016 |
Obatoclax inhibits alphavirus membrane fusion by neutralizing the acidic environment of endocytic compartments FS Varghese, K Rausalu, M Hakanen, S Saul, BM Kümmerer, P Susi, ... Antimicrobial agents and chemotherapy 61 (3), 10.1128/aac. 02227-16, 2017 | 75 | 2017 |
Berberine and obatoclax inhibit SARS-Cov-2 replication in primary human nasal epithelial cells in vitro FS Varghese, E van Woudenbergh, GJ Overheul, MJ Eleveld, L Kurver, ... Viruses 13 (2), 282, 2021 | 73 | 2021 |
Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue K Rausalu, A Utt, T Quirin, FS Varghese, E Žusinaite, PK Das, T Ahola, ... Scientific reports 6 (1), 37124, 2016 | 70 | 2016 |
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 68 | 2023 |
Natural variation in resistance to virus infection in dipteran insects WH Palmer, FS Varghese, RP Van Rij Viruses 10 (3), 118, 2018 | 67 | 2018 |
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine … H Achdout, A Aimon, E Bar-David, GM Morris BioRxiv, 2020 | 55 | 2020 |
Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements CM Crava, FS Varghese, E Pischedda, R Halbach, U Palatini, ... Molecular ecology 30 (7), 1594-1611, 2021 | 49 | 2021 |
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors COVID Moonshot Consortium, H Achdout, A Aimon, DS Alonzi, R Arbon, ... BioRxiv, 2020.10. 29.339317, 2020 | 40 | 2020 |
Insect virus discovery by metagenomic and cell culture-based approaches FS Varghese, RP van Rij Viral Metagenomics: Methods and Protocols, 197-213, 2018 | 10 | 2018 |
Natural variation in resistance to virus infection in dipteran insects. Viruses 10: 118 WH Palmer, FS Varghese, RP Van Rij | 7 | 2018 |
Posaconazole inhibits multiple steps of the alphavirus replication cycle FS Varghese, F Meutiawati, M Teppor, S Jacobs, C de Keyzer, ... Antiviral research 197, 105223, 2022 | 6 | 2022 |
Posaconazole is a novel inhibitor for alphavirus viral entry FS Varghese, F Meutiawati, M Teppor, A Merits, RP Rij Access Microbiology 1 (10), 41, 2019 | 4 | 2019 |
Cracking the code of chikungunya virus: inhibitors as tools to explore alphavirus biology FS Varghese Helsingin yliopisto, 2016 | 2 | 2016 |
Chikungunya virus: Replication & Replication Inhibitors F Varghese | | |