| Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy M Lv, M Chen, R Zhang, W Zhang, C Wang, Y Zhang, X Wei, Y Guan, ... Cell Research, 1-14, 2020 | 585 | 2020 |
| Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses C Wang, Y Guan, M Lv, R Zhang, Z Guo, X Wei, X Du, J Yang, T Li, Y Wan, ... Immunity 48 (4), 675-687. e7, 2018 | 563 | 2018 |
| Activation of STAT6 by STING is critical for antiviral innate immunity H Chen, H Sun, F You, W Sun, X Zhou, L Chen, J Yang, Y Wang, H Tang, ... Cell 147 (2), 436-446, 2011 | 445 | 2011 |
| Mn2+ directly activates cGAS and structural analysis suggests Mn2+ induces a noncanonical catalytic synthesis of 2′ 3′-cGAMP Z Zhao, Z Ma, B Wang, Y Guan, XD Su, Z Jiang Cell reports 32 (7), 2020 | 217 | 2020 |
| MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner R Fang, Q Jiang, X Zhou, C Wang, Y Guan, J Tao, J Xi, JM Feng, Z Jiang PLoS pathogens 13 (11), e1006720, 2017 | 210 | 2017 |
| Manganese salts function as potent adjuvants R Zhang, C Wang, Y Guan, X Wei, M Sha, M Yi, M Jing, M Lv, W Guo, J Xu, ... Cellular & molecular immunology 18 (5), 1222-1234, 2021 | 188 | 2021 |
| Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING R Fang, Q Jiang, Y Guan, P Gao, R Zhang, Z Zhao, Z Jiang Immunity 54 (5), 962-975. e8, 2021 | 111 | 2021 |
| Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure J Ma, A Guillot, Z Yang, B Mackowiak, S Hwang, O Park, BJ Peiffer, ... The Journal of Clinical Investigation 132 (14), 2022 | 50 | 2022 |
| MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression Y Fu, B Mackowiak, D Feng, H Lu, Y Guan, T Lehner, H Pan, XW Wang, ... Gut 72 (10), 1942-1958, 2023 | 40 | 2023 |
| Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death, and lipolysis SH Park, W Seo, MJ Xu, B Mackowiak, Y Lin, Y He, Y Fu, S Hwang, ... Cellular and molecular gastroenterology and hepatology 15 (2), 281-306, 2023 | 37 | 2023 |
| E-selectin-dependent inflammation and lipolysis in adipose tissue exacerbate steatosis-to-NASH progression via S100A8/9 RM Rodrigues, Y He, S Hwang, A Bertola, B Mackowiak, YA Ahmed, ... Cellular and molecular gastroenterology and hepatology 13 (1), 151-171, 2022 | 37 | 2022 |
| NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation F Leng, H Yin, S Qin, K Zhang, Y Guan, R Fang, H Wang, G Li, Z Jiang, ... Scientific Reports 10 (1), 198, 2020 | 37 | 2020 |
| Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models D Feng, X Xiang, Y Guan, A Guillot, H Lu, C Chang, Y He, H Wang, H Pan, ... The Journal of Clinical Investigation 133 (15), 2023 | 34 | 2023 |
| Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners Y Ait Ahmed, Y Fu, RM Rodrigues, Y He, Y Guan, A Guillot, R Ren, ... Cellular & molecular immunology 18 (9), 2165-2176, 2021 | 33 | 2021 |
| Targeting adipose tissue to tackle NASH: SPARCL1 as an emerging player RM Rodrigues, Y Guan, B Gao The Journal of Clinical Investigation 131 (20), 2021 | 14 | 2021 |
| Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption Y Fu, B Mackowiak, YH Lin, L Maccioni, T Lehner, H Pan, Y Guan, ... Nature Metabolism, 1-17, 2024 | 13 | 2024 |
| IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis Y Guan, B Peiffer, D Feng, MA Parra, Y Wang, Y Fu, VH Shah, ... The Journal of Clinical Investigation 134 (9), 2024 | 11 | 2024 |
| Inflammation in alcohol-associated hepatitis: pathogenesis and therapeutic targets D Feng, S Hwang, A Guillot, Y Wang, Y Guan, C Chen, L Maccioni, B Gao Cellular and Molecular Gastroenterology and Hepatology, 2024 | 8 | 2024 |
| Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute‐on‐chronic alcohol‐induced liver injury B Mackowiak, M Xu, Y Lin, Y Guan, W Seo, R Ren, D Feng, JW Jones, ... Alcoholism: Clinical and Experimental Research 46 (12), 2163-2176, 2022 | 7 | 2022 |
| The manganese salt (MnJ) functions as a potent universal adjuvant R Zhang, C Wang, Y Guan, X Wei, M Sha, M Jing, M Lv, J Xu, Y Wan, ... Biorxiv, 783910, 2019 | 4 | 2019 |
