| AMPK as a therapeutic target for treating metabolic diseases EA Day, RJ Ford, GR Steinberg Trends in Endocrinology & Metabolism 28 (8), 545-560, 2017 | 584 | 2017 |
| Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis SL Pinkosky, RS Newton, EA Day, RJ Ford, S Lhotak, RC Austin, ... Nature Communications 7 (1), 13457, 2016 | 445 | 2016 |
| The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels SA Hawley, RJ Ford, BK Smith, GJ Gowans, SJ Mancini, RD Pitt, EA Day, ... Diabetes 65 (9), 2784-2794, 2016 | 356 | 2016 |
| GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease D Wang, EA Day, LK Townsend, D Djordjevic, SB Jørgensen, ... Nature Reviews Endocrinology 17 (10), 592-607, 2021 | 316 | 2021 |
| Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss EA Day, RJ Ford, BK Smith, P Mohammadi-Shemirani, MR Morrow, ... Nature Metabolism 1 (12), 1202-1208, 2019 | 265 | 2019 |
| Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity RJ Ford, MD Fullerton, SL Pinkosky, EA Day, JW Scott, JS Oakhill, ... Biochemical Journal 468 (1), 125-132, 2015 | 187 | 2015 |
| Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models RM Esquejo, CT Salatto, J Delmore, B Albuquerque, A Reyes, Y Shi, ... EBioMedicine 31, 122-132, 2018 | 137 | 2018 |
| Macrophage fumarate hydratase restrains mtRNA-mediated interferon production A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, ... Nature 615 (7952), 490-498, 2023 | 120 | 2023 |
| Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms SL Pinkosky, JW Scott, EM Desjardins, BK Smith, EA Day, RJ Ford, ... Nature metabolism 2 (9), 873-881, 2020 | 115 | 2020 |
| Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-β1 BK Smith, RJ Ford, EM Desjardins, AE Green, MC Hughes, VP Houde, ... Diabetes 65 (11), 3352-3361, 2016 | 81 | 2016 |
| The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue B Wang, EE Tsakiridis, S Zhang, A Llanos, EM Desjardins, JM Yabut, ... Nature communications 12 (1), 5163, 2021 | 79 | 2021 |
| Salicylate improves macrophage cholesterol homeostasis via activation of Ampk MD Fullerton, RJ Ford, CP McGregor, ND LeBlond, SA Snider, SA Stypa, ... Journal of lipid research 56 (5), 1025-1033, 2015 | 70 | 2015 |
| Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance JM Yabut, EM Desjardins, EJ Chan, EA Day, JM Leroux, B Wang, ... Nature communications 11 (1), 463, 2020 | 51 | 2020 |
| The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice EA Day, RJ Ford, JH Lu, R Lu, L Lundenberg, EM Desjardins, AE Green, ... Biochemical Journal 477 (12), 2347-2361, 2020 | 36 | 2020 |
| AMPK mediates energetic stress‐induced liver GDF15 LK Townsend, AJ Weber, EA Day, H Shamshoum, SJ Shaw, CGR Perry, ... The FASEB Journal 35 (1), e21218, 2021 | 35 | 2021 |
| Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans B Scott, EA Day, KL O’Brien, J Scanlan, G Cromwell, AN Scannail, ... Nature Metabolism 6 (4), 651-658, 2024 | 28 | 2024 |
| Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon TAJ Ryan, A Hooftman, AM Rehill, MD Johansen, ECO Brien, ... Nature Communications 14 (1), 3513, 2023 | 26 | 2023 |
| The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils JE Toller-Kawahisa, CH Hiroki, CMS Silva, DC Nascimento, GA Públio, ... Nature Communications 14 (1), 4280, 2023 | 21 | 2023 |
| GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury K Platko, PF Lebeau, JH Byun, SV Poon, EA Day, ME MacDonald, ... Molecular metabolism 27, 62-74, 2019 | 20 | 2019 |
| The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids EM Desjardins, BK Smith, EA Day, S Ducommun, MJ Sanders, ... Proceedings of the National Academy of Sciences 119 (48), e2119824119, 2022 | 19 | 2022 |