Inhibitors of mitochondrial Kv1. 3 channels induce Bax/Bak‐independent death of cancer cells L Leanza, B Henry, N Sassi, M Zoratti, KG Chandy, E Gulbins, I Szabò EMBO molecular medicine 4 (7), 577-593, 2012 | 198 | 2012 |
Intracellular ion channels and cancer L Leanza, L Biasutto, A Managò, E Gulbins, M Zoratti, I Szabò Frontiers in physiology 4, 227, 2013 | 170 | 2013 |
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo L Leanza, M Romio, KA Becker, M Azzolini, L Trentin, A Manago, ... Cancer cell 31 (4), 516-531. e10, 2017 | 167 | 2017 |
Mitochondrial dynamics, ROS, and cell signaling: a blended overview V Brillo, L Chieregato, L Leanza, S Muccioli, R Costa Life 11 (4), 332, 2021 | 153 | 2021 |
Pharmacological targeting of ion channels for cancer therapy: in vivo evidences L Leanza, A Manago, M Zoratti, E Gulbins, I Szabo Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (6), 1385-1397, 2016 | 131 | 2016 |
Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1. 3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia L Leanza, L Trentin, KA Becker, F Frezzato, M Zoratti, G Semenzato, ... Leukemia 27 (8), 1782-1785, 2013 | 106 | 2013 |
Mitochondrial ion channels as oncological targets L Leanza, M Zoratti, E Gulbins, I Szabo Oncogene 33 (49), 5569-5581, 2014 | 101 | 2014 |
Physiology of potassium channels in the inner membrane of mitochondria I Szabò, L Leanza, E Gulbins, M Zoratti Pflügers Archiv-European Journal of Physiology 463, 231-246, 2012 | 99 | 2012 |
Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction R Costa, R Peruzzo, M Bachmann, G Dalla Monta, M Vicario, G Santinon, ... Cell reports 28 (8), 1949-1960. e6, 2019 | 81 | 2019 |
Early effects of the antineoplastic agent salinomycin on mitochondrial function A Managò, L Leanza, L Carraretto, N Sassi, S Grancara, ... Cell death & disease 6 (10), e1930-e1930, 2015 | 79 | 2015 |
Induction of apoptosis in macrophages via Kv1. 3 and Kv1. 5 potassium channels L Leanza, M Zoratti, E Gulbins, I Szabo Current medicinal chemistry 19 (31), 5394-5404, 2012 | 78 | 2012 |
Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax-and Bak-less mouse embryonic fibroblasts: novel insights into the molecular … I Szabò, M Soddemann, L Leanza, M Zoratti, E Gulbins Cell Death & Differentiation 18 (3), 427-438, 2011 | 77 | 2011 |
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines L Leanza, P O'Reilly, A Doyle, E Venturini, M Zoratti, E Szegezdi, I Szabo Current pharmaceutical design 20 (2), 189-200, 2014 | 74 | 2014 |
Thylakoid potassium channel is required for efficient photosynthesis in cyanobacteria V Checchetto, A Segalla, G Allorent, N La Rocca, L Leanza, ... Proceedings of the National Academy of Sciences 109 (27), 11043-11048, 2012 | 74 | 2012 |
Physiology of intracellular potassium channels: A unifying role as mediators of counterion fluxes? V Checchetto, E Teardo, L Carraretto, L Leanza, I Szabo Biochimica et Biophysica Acta (BBA)-Bioenergetics 1857 (8), 1258-1266, 2016 | 67 | 2016 |
Targeting a mitochondrial potassium channel to fight cancer L Leanza, E Venturini, S Kadow, A Carpinteiro, E Gulbins, KA Becker Cell calcium 58 (1), 131-138, 2015 | 67 | 2015 |
Impact of intracellular ion channels on cancer development and progression R Peruzzo, L Biasutto, I Szabò, L Leanza European Biophysics Journal 45, 685-707, 2016 | 57 | 2016 |
Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma A Zaccagnino, A Managò, L Leanza, A Gontarewitz, B Linder, M Azzolini, ... Oncotarget 8 (24), 38276, 2016 | 56 | 2016 |
Pharmacological modulation of mitochondrial ion channels L Leanza, V Checchetto, L Biasutto, A Rossa, R Costa, M Bachmann, ... British journal of pharmacology 176 (22), 4258-4283, 2019 | 49 | 2019 |
Targeting the potassium channel Kv1. 3 kills glioblastoma cells E Venturini, L Leanza, M Azzolini, S Kadow, A Mattarei, M Weller, ... Neurosignals 25 (1), 26-38, 2018 | 49 | 2018 |