Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous
epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) …

Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The
dynamic regulation of cadherins in response to various extracellular signals controls cell …

Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and
asthma exacerbations compared with other rhinoviruses. The cellular receptor for these …

Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist
mechanical stress because they adopt a strongly adhesive state in which they are said to be …

Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising
from sound waves and head movement into electrochemical signals to provide our sense of …

The use of nanomaterials has raised safety concerns, as their small size facilitates
accumulation in and interaction with biological tissues. Here we show that exposure of …

The loss of E-cadherin expression in association with the epithelial–mesenchymal transition
(EMT) occurs frequently during tumor metastasis. However, metastases often retain E …