Dietary fiber and SCFAs in the regulation of mucosal immunity
Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …
The sporobiota of the human gut
The human gut microbiome is a diverse and complex ecosystem that plays a critical role in
health and disease. The composition of the gut microbiome has been well studied across all …
health and disease. The composition of the gut microbiome has been well studied across all …
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles
The microbiome modulates host immunity and aids the maintenance of tolerance in the gut,
where microbial and food-derived antigens are abundant. Yet modern dietary factors and …
where microbial and food-derived antigens are abundant. Yet modern dietary factors and …
Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance
F De Filippis, L Paparo, R Nocerino… - Nature …, 2021 - nature.com
Understanding the functional potential of the gut microbiome is of primary importance for the
design of innovative strategies for allergy treatment and prevention. Here we report the gut …
design of innovative strategies for allergy treatment and prevention. Here we report the gut …
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes
X Yuan, R Wang, B Han, CJ Sun, R Chen… - Nature …, 2022 - nature.com
Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D
remains unclear. Here, we integratively profiled gut microbial functional and metabolic …
remains unclear. Here, we integratively profiled gut microbial functional and metabolic …
[HTML][HTML] Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation
A Trompette, J Pernot, O Perdijk, RAA Alqahtani… - Mucosal …, 2022 - Elsevier
Barrier integrity is central to the maintenance of healthy immunological homeostasis.
Impaired skin barrier function is linked with enhanced allergen sensitization and the …
Impaired skin barrier function is linked with enhanced allergen sensitization and the …
[HTML][HTML] S3 guideline allergy prevention
MV Kopp, C Muche-Borowski, M Abou-Dakn… - Allergologie …, 2022 - ncbi.nlm.nih.gov
Background: The persistently high prevalence of allergic diseases in Western industrial
nations and the limited possibilities of causal therapy make evidence-based …
nations and the limited possibilities of causal therapy make evidence-based …
Butyrate shapes immune cell fate and function in allergic asthma
The microbiome plays a fundamental role in how the immune system develops and how
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …
Perinatal and early-life nutrition, epigenetics, and allergy
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …
prevalence of allergic diseases over the last several decades. Environmental triggers …