Recent progress concerning CpG DNA and its use as a vaccine adjuvant

H Shirota, DM Klinman - Expert review of vaccines, 2014 - Taylor & Francis
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to
specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding …

Transcutaneous immunization: an overview of advantages, disease targets, vaccines, and delivery technologies

P Karande, S Mitragotri - Annual review of chemical and …, 2010 - annualreviews.org
Skin is an immunologically active tissue composed of specialized cells and agents that
capture and process antigens to confer immune protection. Transcutaneous immunization …

The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

S Navarro, G Cossalter, C Chiavaroli, A Kanda… - Mucosal …, 2011 - nature.com
The prevalence of asthma has steadily increased during the last decade, probably as the
result of changes in the environment, including reduced microbial exposure during infancy …

Intranasal Vaccination with a Secreted Chlamydial Protein Enhances Resolution of Genital Chlamydia muridarum Infection, Protects against Oviduct Pathology, and …

AK Murthy, JP Chambers, PA Meier, G Zhong… - Infection and …, 2007 - journals.asm.org
There is currently no licensed vaccine against Chlamydia trachomatis, the leading cause of
sexually transmitted bacterial disease worldwide. Conventional vaccination attempts using …

Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts

KL Asquith, JC Horvat, GE Kaiko, AJ Carey… - PLoS …, 2011 - journals.plos.org
Chlamydiae are intracellular bacteria that commonly cause infections of the respiratory and
genital tracts, which are major clinical problems. Infections are also linked to the aetiology of …

The Duration of Chlamydia muridarum Genital Tract Infection and Associated Chronic Pathological Changes Are Reduced in IL-17 Knockout Mice but Protection Is …

DW Andrew, M Cochrane, JH Schripsema… - PloS one, 2013 - journals.plos.org
IL-17 is believed to be important for protection against extracellular pathogens, where
clearance is dependent on neutrophil recruitment and local activation of epithelial cell …

TLR2, but Not TLR4, Is Required for Effective Host Defence against Chlamydia Respiratory Tract Infection in Early Life

EL Beckett, S Phipps, MR Starkey, JC Horvat… - PloS one, 2012 - journals.plos.org
Chlamydia pneumoniae commonly causes respiratory tract infections in children, and
epidemiological investigations strongly link infection to the pathogenesis of asthma. The …

Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology

JJ Woods, KA Skelding, KL Martin, R Aryal… - Brain, behavior, and …, 2020 - Elsevier
Alzheimer's disease, the most common form of dementia, was first formally described in
1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of …

A Multi‐Subunit Chlamydial Vaccine Induces Antibody and Cell‐Mediated Immunity in Immunized Koalas (Phascolarctos cinereus): Comparison of Three Different …

AJ Carey, P Timms, G Rawlinson… - American journal of …, 2010 - Wiley Online Library
Citation Carey AJ, Timms P, Rawlinson G, Brumm J, Nilsson K, Harris JM, Beagley KW. A
multi‐subunit chlamydial vaccine induces antibody and cell‐mediated immunity in …

Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum …

Y Cong, M Jupelli, MN Guentzel, G Zhong, AK Murthy… - Vaccine, 2007 - Elsevier
We have reported recently that intranasal (in) vaccination with chlamydial protease-like
activity factor (CPAF) and interleukin-12 (IL-12) enhances protective immunity against …