Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although
AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very …

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …