The ST6GAL1 sialyltransferase, which adds α2–6 linked sialic acids to N-glycosylated
proteins, is overexpressed in a wide range of human malignancies. Recent studies have …

Background Glycosylation is increasingly recognized as one of the most relevant
postranslational modifications. Sialic acids are negatively charged sugars which frequently …

Background Ovarian adenocarcinoma is not generally discovered in patients until there has
been widespread intraperitoneal dissemination, which is why ovarian cancer is the deadliest …

Background Cell surface sialylation is emerging as an important feature of cancer cell
metastasis. Sialyltransferase expression has been reported to be altered in tumours and …

Programmed cell death promotes homeostatic cell turnover in the epithelium but is
dysregulated in cancer. The glycosyltransferase ST6Gal-I is known to block homeostatic …

Purpose One of the typical modifications on the surface of cancer cells is sialylation of
terminal carbohydrates. The expression of several types of sialylation of glycoconjugates …

Different genetic routes account for colonic carcinogenesis. However, when analyzing colon
cancer specimens, separation into different groups based on genetic alterations is …

Sialic acid, a nine-carbon sugar acid usually is present in the non-reducing terminal position
of free oligosaccharides and glycoconjugates. Sialylated conjugates in mammals perform …

Abstract Background Increased ST6Gal I activity has been associated with the α (2, 6)
sialylation enhancement of membrane glycoconjugates observed in metastatic colorectal …

Aberrant expression of glycoconjugates occurs during malignant transformation of cancer
cells. Overexpression of sialoglycoconjugates in particular may play an important role in the …