By the last third of life, most mammals, including humans, exhibit a decline in immune cell
numbers, immune organ structure, and immune defense of the organism, commonly known …

Toxoplasma gondii is an obligate intracellular parasite considered one of the most
successful pathogens in the world, owing to its ability to produce long-lasting infections and …

It is well established that decreased brain blood flow, increased reactive oxygen species
production (ROS), and pro-inflammatory mechanisms accelerate neurodegenerative …

Toxoplasma gondii, an obligate intracellular pathogen, induces a strong immune response
in the infected host. In the encephalitis model of infection, long-term protective immunity is …

We are entering a 'Platinum Age of Virus Discovery', an era marked by exponential growth in
the discovery of virus biodiversity, and driven by advances in metagenomics and …

Cellular barcoding techniques are powerful tools to understand microbial pathogenesis.
However, barcoding strategies have not been broadly applied to protozoan parasites, which …

Toxoplasma gondii, an obligate intracellular protozoan parasite, can establish a chronic
infection in the brain by forming tissue cysts. This chronic infection is widespread in humans …

The human microbiome (commensal microbes) and pathobiome (disease causing
microbes) establish a delicate balance with the immune system. The immune system is a …