The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …

Map** the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

The volume and composition of a thin layer of liquid covering the airway surface defend the
lung from inhaled pathogens and debris. Airway epithelia secrete Cl–into the airway surface …

Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …

Muco-obstructive lung diseases are typically associated with high risks of COVID-19
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …

Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000
people. People with CF experience multi-organ dysfunction resulting from aberrant …

Speciation leads to adaptive changes in organ cellular physiology and creates challenges
for studying rare cell-type functions that diverge between humans and mice. Rare cystic …

The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …