Ionizing radiation interacts with the immune system in many ways with a multiplicity that
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …

Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Background Radiation-induced lung fibrosis (RILF) is a severe and life-threatening
complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a …

A limit to the clinical benefit of radiotherapy is not an incapacity to eliminate tumor cells but
rather a limit on its capacity to do so without destroying normal tissue and inducing …

Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

Radiation therapy (RT) is a cornerstone in oncologic management and is employed in
various curative and palliative scenarios for local-regional control. RT is thought to locally …

Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic
radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a …

Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …

Chimeric antigen receptor T-cell (CAR-T) therapy demonstrates impressive efficacy in
relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, CAR-T therapy …

Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …