▪ Abstract Advances in the molecular biology of human diseases indicate that the most
striking manifestations of illness may be caused not by exogenous pathogenic or tumor …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Background A recombinant, soluble fusion protein that is a dimer of an extracellular portion
of the human tumor necrosis factor (TNF) receptor and the Fc portion of IgG1 (TNFR: Fc) …

Endotoxemia was evoked by bolus injection of Escherichia coli endotoxin (2 ng/kg body
weight) in six healthy subjects to investigate the early kinetics of cytokine release in relation …

In addition to activating T and B lymphocytes, interleukin 1 (IL-1) induces several
hematologic and metabolic changes typical of host responses to infection and injury. We …

To define the mechanism (s) responsible for the negative inotropic effects of tumor necrosis
factor-alpha (TNF alpha) in the adult heart, we examined the functional effects of TNF alpha …

Cytokines are recognized as critical early mediators of organ injury. We attempted to
determine whether or not severe hepatic ischemia/reperfusion injury results in tumor …

Cachexia is a potentially lethal syndrome of unknown etiology characterized by anorexia,
weight loss, and protein wasting that frequently complicates the treatment of chronic …

Cytokines secreted in response to invading micro-organisms are important mediators of
detrimental hemodynamic and metabolic changes in the host. To test whether cachectin/TNF …

Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …