Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Retroviruses infect a broad range of vertebrate hosts that includes amphibians, reptiles, fish,
birds and mammals. In addition, a typical vertebrate genome contains thousands of loci …

The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained
elusive. A new category of pathogenic components, normally dormant within human …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

We analyze whole-genome sequencing data from 141,431 Chinese women generated for
non-invasive prenatal testing (NIPT). We use these data to characterize the population …

The human genome contains a large number of retroviral elements acquired over the
process of evolution, some of which are specific to primates. However, as many of these are …

Transposable Elements (TE) are mobile DNA elements that can replicate and insert
themselves into different locations within the host genome. Their propensity to self …

Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in
cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA …