Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024‏ - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Multienzyme‐like nanozymes: regulation, rational design, and application

J Sheng, Y Wu, H Ding, K Feng, Y Shen… - Advanced …, 2024‏ - Wiley Online Library
Nanomaterials with more than one enzyme‐like activity are termed multienzymic
nanozymes, and they have received increasing attention in recent years and hold huge …

Coordination-driven self-assembly strategy-activated Cu single-atom nanozymes for catalytic tumor-specific therapy

J Zhou, D Xu, G Tian, Q He, X Zhang… - Journal of the …, 2023‏ - ACS Publications
How to optimize the enzyme-like catalytic activity of nanozymes to improve their applicability
has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven …

Biosystem‐inspired engineering of nanozymes for biomedical applications

L Zhang, H Wang, X Qu - Advanced Materials, 2024‏ - Wiley Online Library
Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to
become surrogates of natural enzymes in many fields by virtue of their advantages of high …

Catalase‐like nanozymes: Classification, catalytic mechanisms, and their applications

D Xu, L Wu, H Yao, L Zhao - Small, 2022‏ - Wiley Online Library
The field of nanozymes has developed rapidly over the past decade. Among various
oxidoreductases mimics, catalase (CAT)‐like nanozyme, acting as an essential part of the …

Designing nanozymes for in vivo applications

R Zhang, B Jiang, K Fan, L Gao, X Yan - Nature Reviews …, 2024‏ - nature.com
Biocatalytic drugs, including natural and artificial enzymes that can accelerate biochemical
reactions, are promising tools to address redox imbalances, metabolic disorders and …

Nanozymes-recent development and biomedical applications

X Ren, D Chen, Y Wang, H Li, Y Zhang, H Chen… - Journal of …, 2022‏ - Springer
Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with
the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are …

Multifunctional mesoporous silica nanoparticles for biomedical applications

B Xu, S Li, R Shi, H Liu - Signal transduction and targeted therapy, 2023‏ - nature.com
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

Tumor‐microenvironment‐responsive cascade reactions by a cobalt‐single‐atom nanozyme for synergistic nanocatalytic chemotherapy

S Cai, J Liu, J Ding, Z Fu, H Li, Y **ong… - Angewandte …, 2022‏ - Wiley Online Library
Nanocatalytic therapy, involving the nanozyme‐triggered production of reactive oxygen
species (ROS) in the tumor microenvironment (TME), has demonstrated potential in tumor …

Transition-metal-based nanozymes: synthesis, mechanisms of therapeutic action, and applications in cancer treatment

Q Fu, C Wei, M Wang - ACS nano, 2024‏ - ACS Publications
Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-
edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as …